Host responses from innate to adaptive immunity after vaccination: molecular and cellular events.
Host responses from innate to adaptive immunity after vaccination: molecular and cellular events.
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DOI：
10.1007/s10059-009-0015-1
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发表时间：
2009-01-31
影响因子：
3.8
通讯作者：
Compans RW
中科院分区：
文献类型：
--
作者：
Kang SM;Compans RW
有效疫苗的供应对预防传染病、提高公共卫生质量产生了最深远的积极影响。尽管有许多成功的疫苗，但仍有一些新老病原体没有可用的疫苗。更好地了解疫苗如何提供保护将有助于改进现有疫苗，并开发针对我们没有适当控制手段的病原体的有效疫苗。最近的研究集中在先天免疫作为宿主防御的第一道防线及其在诱导适应性免疫中的作用;这些研究一直是一个激烈的研究领域，这将揭示疫苗如何发挥保护作用的免疫学机制。Toll样受体（TLR）是先天免疫系统细胞上病原体相关分子模式的受体家族，在检测和响应微生物感染中起关键作用。重要的是，先天免疫系统调节长期T和B细胞记忆和对病原体的保护性免疫应答的数量和质量。有限的研究表明，模拟自然感染和/或病原体结构的疫苗似乎能有效诱导长期保护性免疫。更好地了解宿主对疫苗接种和病原体感染的反应中分子和细胞事件的相似性和差异性，将为设计针对许多挑战性病原体的新型预防措施提供理论基础。
The availability of effective vaccines has had the most profound positive effect on improving the quality of public health by preventing infectious diseases. Despite many successful vaccines, there are still old and new emerging pathogens against which there is no vaccine available. A better understanding of how vaccines work for providing protection will help to improve current vaccines as well as to develop effective vaccines against pathogens for which we do not have a proper means to control. Recent studies have focused on innate immunity as the first line of host defense and its role in inducing adaptive immunity; such studies have been an intense area of research, which will reveal the immunological mechanisms how vaccines work for protection. Toll-like receptors (TLRs), a family of receptors for pathogen-associated molecular patterns on cells of the innate immune system, play a critical role in detecting and responding to microbial infections. Importantly, the innate immune system modulates the quantity and quality of longterm T and B cell memory and protective immune responses to pathogens. Limited studies suggest that vaccines which mimic natural infection and/or the structure of pathogens seem to be effective in inducing long-term protective immunity. A better understanding of the similarities and differences of the molecular and cellular events in host responses to vaccination and pathogen infection would enable the rationale for design of novel preventive measures against many challenging pathogens.
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影响因子：
3.7
作者：
Bright RA;Carter DM;Crevar CJ;Toapanta FR;Steckbeck JD;Cole KS;Kumar NM;Pushko P;Smith G;Tumpey TM;Ross TM
通讯作者：
Ross TM
影响因子：
3.7
作者：
Deml, L;Schirmbeck, R;Wagner, R
通讯作者：
Wagner, R
影响因子：
5.4
作者：
Buonaguro, L.;Tornesello, M. L.;Buonaguro, F. M.
通讯作者：
Buonaguro, F. M.
影响因子：
4.4
作者：
Crotty, S;Felgner, P;Ahmed, R
通讯作者：
Ahmed, R
影响因子：
5.5
作者：
Auewarakul, Prasert;Kositanont, Uraiwan;Thongcharoen, Prasert
通讯作者：
Thongcharoen, Prasert