A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases.
A major house dust mite allergen disrupts the immunoglobulin E network by selectively cleaving CD23: innate protection by antiproteases.
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主要的屋尘螨过敏原通过选择性裂解 CD23（抗蛋白酶的先天保护）来破坏免疫球蛋白 E 网络。
DOI：
10.1084/jem.182.5.1537
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发表时间：
1995-11-01
期刊：
影响因子：
--
通讯作者：
Pritchard DI
中科院分区：
文献类型：
--
作者：
Hewitt CR;Brown AP;Hart BJ;Pritchard DI
Asthma is a chronic life-threatening disease of worldwide importance. Although allergic asthma and related atopic conditions correlate strongly with immune sensitization to house dust mites, it is unclear why antigens from mites provoke such powerful allergic immune responses. We have characterized the protease activity of Der p I, the group I protease allergen of the house dust mite Dermatophagoides pteronyssinus, and here report that it cleaves the low-affinity immunoglobulin (Ig) E Fc receptor (CD23) from the surface of human B lymphocytes. Der p I selectively cleaves CD23 and has no effect on the expression of any other B cell surface molecules tested. We speculate that this loss of cell surface CD23 from IgE-secreting B cells may promote and enhance IgE immune responses by ablating an important feedback inhibitory mechanism that normally limits IgE synthesis. Furthermore, since soluble CD23 is reported to promote IgE production, fragments of CD23 released by Der p I may directly enhance the synthesis of IgE. alpha 1-Antiprotease, a pulmonary antiprotease, is also shown to inhibit the cleavage of CD23 by Der p I. This may be significant in the etiopathogenesis of asthma, because other indoor pollutants associated with asthma are known to potently inhibit this antiprotease. These data suggest that the proteolytic activity of Der p I, the group I allergen of the house dust mite D. pteronyssinus, is mechanistically linked to the potent allergenicity of house dust mites. Furthermore, inhibition of Der p I by alpha 1-antiprotease suggests a mechanism by which confounding factors, such as tobacco smoke, may act as a risk factor for allergic asthma.
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DOI：
10.1073/pnas.86.18.7118
发表时间：
1989-09-01
影响因子：
11.1
作者：
BETTLER, B;MAIER, R;HOFSTETTER, H
通讯作者：
HOFSTETTER, H
影响因子：
4.4
作者：
FINKELMAN, FD;URBAN, JF;KATONA, IM
通讯作者：
KATONA, IM
影响因子：
3.6
作者：
LETELLIER, M;SARFATI, M;DELESPESSE, G
通讯作者：
DELESPESSE, G
DOI：
10.1159/000235402
发表时间：
1991-01-01
期刊：
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY
影响因子：
--
作者：
LAKE, FR;WARD, LD;STEWART, GA
通讯作者：
STEWART, GA
影响因子：
14.2
作者：
CARTIER, A;MALO, JL;DOLOVICH, J
通讯作者：
DOLOVICH, J