Immunity's fourth dimension: approaching the circadian-immune connection.
Immunity's fourth dimension: approaching the circadian-immune connection.
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DOI：
10.1016/j.it.2012.08.007
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发表时间：
2012-12
影响因子：
16.8
通讯作者：
Fikrig E
中科院分区：
文献类型：
--
作者：
Arjona A;Silver AC;Walker WE;Fikrig E
The circadian system ensures the generation and maintenance of self-sustained ~24 h rhythms in physiology that are linked to internal and environmental changes. In mammals, daily variations in light intensity and other cues are integrated by a hypothalamic master clock that conveys circadian information to peripheral molecular clocks that orchestrate physiology. Multiple immune parameters also vary throughout the day and disruption of circadian homeostasis is associated with immune-related disease. Here we discuss the molecular links between the circadian and immune systems and examine their outputs and disease implications. Understanding the mechanisms that underlie circadian-immune crosstalk may prove valuable for devising novel prophylactic and therapeutic interventions.
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影响因子：
4.4
作者：
Alten, Rieke
通讯作者：
Alten, Rieke
DOI：
10.1126/science.1180962
发表时间：
2009-11-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kang JE;Lim MM;Bateman RJ;Lee JJ;Smyth LP;Cirrito JR;Fujiki N;Nishino S;Holtzman DM
通讯作者：
Holtzman DM
影响因子：
3.7
作者：
Bhardwaj V;Meier S;Petersen LN;Ingle RA;Roden LC
通讯作者：
Roden LC
DOI：
10.1621/nrs.07003
发表时间：
2009
期刊：
Nuclear receptor signaling
影响因子：
--
作者：
Jetten AM
通讯作者：
Jetten AM
影响因子：
4.5
作者：
Liu AC;Tran HG;Zhang EE;Priest AA;Welsh DK;Kay SA
通讯作者：
Kay SA