Endothelins regulate mediator production of rat tissue‐cultured mucosal mast cells. Up‐regulation of Th1 and inhibition of Th2 cytokines
Endothelins regulate mediator production of rat tissue‐cultured mucosal mast cells. Up‐regulation of Th1 and inhibition of Th2 cytokines
复制标题
内皮素调节大鼠组织培养的粘膜肥大细胞的介质产生，上调 Th1 并抑制 Th2 细胞因子。
DOI：
10.1189/jlb.71.5.829
复制
发表时间：
2002
影响因子：
5.5
通讯作者：
É. Bissonnette
中科院分区：
文献类型：
--
作者：
Martin Coulombe;B. Battistini;J. Stankova;P. Pouliot;É. Bissonnette
Mast cells have been shown to produce endothelin‐1 (ET‐1) and to express ET receptors. Thus, we postulated that ETs modulate mast cell mediator production in an autocrine manner. Rat tissue‐cultured mast cells (RCMC‐1) were incubated with exogenous ET‐1 or ET‐3, and β‐hexosaminidase release and TNF, IL‐4, IL‐10, IL‐12, IL‐13, macrophage inflammatory protein‐1α (MIP‐1α), and nitric oxide (NO) production were investigated. ET‐1 and ‐3 induced the release of β‐hexosaminidase and TNF and of mRNA expression. An antagonist of the ETB receptor subtype abrogated ET‐stimulated TNF release, although ETA and ETB receptors have been identified by immunocytochemistry. It is interesting that ET‐1 and ET‐3 inhibited (25–30%) mRNA expression of Th2‐type cytokines (IL‐4, IL‐10, and IL‐13) and increased IL‐12 release (39% and 41%, respectively) without affecting MIP‐1α and NO production. Thus, our data suggest that ETs may play an important role in modulating the cytokine network by regulating Th1/Th2 cytokine production by mast cells.
ET-1从豚鼠肺部释放组胺，但不从腹膜肥大细胞释放组胺。
DOI：
10.1016/0006-291x(92)92331-q
发表时间：
1992
影响因子：
3.1
作者：
Uchida,Y;Ninomiya,H;Sakamoto,T;Lee,JY;Endo,T;Nomura,A;Hasegawa,S;Hirata,F
通讯作者：
Hirata,F