Concomitant Pathogenic Mutations and Fusions of Driver Oncogenes in Tumors.
Concomitant Pathogenic Mutations and Fusions of Driver Oncogenes in Tumors.
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肿瘤中驱动癌基因的伴随致病突变和融合
DOI：
10.3389/fonc.2020.544579
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发表时间：
2020
影响因子：
4.7
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Zhang R;Dong L;Yu J
驱动癌基因改变一直是肿瘤发生发展过程中的主要原因之一。驱动癌基因改变对不同类型肿瘤发生发展的影响已被广泛研究。在以往的研究中已经明确阐明了驱动癌基因改变的作用。伴随驱动癌基因突变和驱动基因融合的现象在过去二十年中得到了广泛关注。越来越多的研究报告了这种现象，要么共存，要么相互排斥。本文综述了肺癌、甲状腺癌和白血病这三种常见癌症的伴随突变现象，这三种癌症的研究相对更详细、更普遍。
Driver oncogene alterations have always been one of leading causes in the process of occurrence and development of tumors. And the effects of driver oncogene alterations on tumorigenesis and progression in different kinds of tumors have been studied heatedly. And the roles that the driver oncogenes alterations play have been elucidated clearly in previous studies. The phenomenon of concomitant driver oncogenes mutations and driver genes fusions has gained much concentration in the past two decades. And a growing number of studies reported this phenomenon, either coexistence or mutually exclusivity. Here we reviewed on the phenomenon of concomitant mutations in three common types of carcinomas—lung cancer, thyroid cancer, and leukemia, which have been studied relatively more detailed and more general compared with others.
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影响因子：
64.5
作者：
Cancer Genome Atlas Research Network
通讯作者：
Cancer Genome Atlas Research Network
DOI：
10.1158/1078-0432.ccr-08-0933
发表时间：
2009-01-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Henderson YC;Shellenberger TD;Williams MD;El-Naggar AK;Fredrick MJ;Cieply KM;Clayman GL
通讯作者：
Clayman GL
影响因子：
30.8
作者：
Faber ZJ;Chen X;Gedman AL;Boggs K;Cheng J;Ma J;Radtke I;Chao JR;Walsh MP;Song G;Andersson AK;Dang J;Dong L;Liu Y;Huether R;Cai Z;Mulder H;Wu G;Edmonson M;Rusch M;Qu C;Li Y;Vadodaria B;Wang J;Hedlund E;Cao X;Yergeau D;Nakitandwe J;Pounds SB;Shurtleff S;Fulton RS;Fulton LL;Easton J;Parganas E;Pui CH;Rubnitz JE;Ding L;Mardis ER;Wilson RK;Gruber TA;Mullighan CG;Schlenk RF;Paschka P;Döhner K;Döhner H;Bullinger L;Zhang J;Klco JM;Downing JR
通讯作者：
Downing JR
影响因子：
5.8
作者：
Fenton, CL;Lukes, Y;Tuttle, RM
通讯作者：
Tuttle, RM
DOI：
10.1093/jnci/95.8.625
发表时间：
2003-04-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Cohen, J;Xing, MZ;Sidransky, D
通讯作者：
Sidransky, D