Modeling the interactions between deformable capsules rolling on a compliant surface.
Modeling the interactions between deformable capsules rolling on a compliant surface.
复制标题
对在柔顺表面上滚动的可变形胶囊之间的相互作用进行建模。
作者：
A. Alexeev;R. Verberg;A. Balazs
通过整合流体力学和微观力学的介观模型，我们研究了流体驱动的运动对胶囊的顺应性，粘合剂基板。被建模为流体填充的弹性壳的胶囊代表细胞或聚合物微胶囊。我们表明，两个紧密间隔的，滚动胶囊的相对速度和平均速度取决于胶囊的弹性，胶囊和基板之间的粘合剂相互作用，以及基板的顺应性。我们首先关注刚性表面，发现刚性胶囊对总是彼此分离，而对于可变形胶囊，动态行为关键取决于粘合剂相互作用的强度。对于与基底的强粘附，胶囊再次彼此滚离，而对于相对弱的粘附，胶囊实际上彼此接近。在软基底的情况下，由胶囊引起的表面的任何显著变形都会产生推动颗粒快速分开的力。因此，在胶囊与软质基底之间粘附力较强的情况下，刚性胶囊和柔性胶囊都被驱动分离。另一方面，对于弱粘附，弹性颗粒彼此接近，类似于刚性表面上的行为。这些发现揭示了胶囊之间的相互作用是由底层的性质介导的。我们可以利用这些信息来设计表面，主动控制胶囊之间的相对距离。这可以用来调节生物细胞的运动，以及聚合物微胶囊，因此，可以证明是有用的各种生物测定或组织工程研究。
By integrating mesoscale models for hydrodynamics and micromechanics, we examine the fluid-driven motion of pairs of capsules on a compliant, adhesive substrate. The capsules, modeled as fluid filled elastic shells, represent cells or polymeric microcapsules. We show that both the relative and the average velocities of two closely spaced, rolling capsules depends on the elasticity of the capsules, the adhesive interaction between the capsules and the substrate, and the compliance of the substrate. We first focused on a stiff surface and found that pairs of rigid capsules always separate from each other, while for deformable capsules, the dynamic behavior depends critically on the strength of the adhesive interaction. For strong adhesion to the substrate, the capsules again roll away from each other, while for a relatively weak adhesion, the capsules actually approach each other. In the case of soft substrates, any significant deformations of the surface that are caused by the capsules give rise to a force that propels the particles to move rapidly apart. Thus, in the case of strong adhesion between the capsules and the soft substrates, both rigid and flexible capsules are driven to separate. On the other hand, for weak adhesion, the elastic particles approach each other, similar to the behavior on stiff surfaces. These findings reveal that the interactions between the capsules are mediated by the nature of the underlying layer. We can harness this information to design surfaces that actively control the relative separation between the capsules. This could be utilized to regulate the motion of biological cells, as well as polymeric microcapsules, and thus, could prove to be useful in various biological assays or tissue engineering studies.
影响因子：
56.9
作者：
Burns, MA;Johnson, BN;Burke, DT
通讯作者：
Burke, DT
影响因子：
3.1
作者：
D. Khismatullin;G. Truskey
通讯作者：
D. Khismatullin;G. Truskey