Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies.
Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies.
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DOI：
10.1007/82_2014_413
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发表时间：
2015
影响因子：
--
通讯作者：
Wilson, Ian A.
中科院分区：
文献类型：
--
作者：
Lee, Peter S.;Wilson, Ian A.
流感血凝素 (HA) 是流感病毒的主要表面糖蛋白，介导病毒附着以及随后与宿主细胞的融合。 HA 是免疫反应的主要目标，但由于其高度可变性（如大量抗原多样性所证明），历史上它被认为只能引发狭窄的、菌株特异性的抗体反应。然而，最近针对流感病毒的广泛中和抗体 (bnAb) 的大量发现，通过 HA-抗体复合物的结构表征，确定了 HA 上两个主要的脆弱性超级位点。这些常见的目标表位与受体结合以及融合机制有关，因此在功能上是保守的并且不易发生突变。这些 bnAb 可以通过阻止感染来中和病毒，或者通过阻止后代释放来中和病毒。对这些 bnAb 的结构分析表明，尽管它们的种系基因存在显着差异，但它们在识别 HA 和使用重复识别基序方面表现出惊人的相似性和趋势。这些信息可用于设计新型疗法以及免疫原，以改进具有更大广度和功效的疫苗。
Influenza hemagglutinin (HA) is the major surface glycoprotein on influenza viruses and mediates viral attachment and subsequent fusion with host cells. The HA is the major target of the immune response, but due to its high level of variability, as evidenced by substantial antigenic diversity, it had been historically considered to elicit only a narrow, strain-specific antibody response. However, a recent explosion in the discovery of broadly neutralizing antibodies (bnAbs) to influenza virus has identified two major supersites of vulnerability on the HA through structural characterization of HA-antibody complexes. These commonly targeted epitopes are involved with receptor binding as well as the fusion machinery and, hence, are functionally conserved and less prone to mutation. These bnAbs can neutralize viruses by blocking infection or the spread of infection by preventing progeny release. Structural analyses of these bnAbs show they exhibit striking similarities and trends in recognition of the HA and use recurring recognition motifs, despite substantial differences in their germline genes. This information can be utilized in design of novel therapeutics as well as in immunogens for improved vaccines with greater breadth and efficacy.
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影响因子：
8.7
作者：
Julien JP;Lee PS;Wilson IA
通讯作者：
Wilson IA
人类感染新型禽源甲型流感 (H7N9) 病毒。
影响因子：
158.5
作者：
Gao, Rongbao;Cao, Bin;Shu, Yuelong
通讯作者：
Shu, Yuelong
DOI：
10.1073/pnas.1319058110
发表时间：
2014-01-07
影响因子：
11.1
作者：
Friesen, Robert H. E.;Lee, Peter S.;Wilson, Ian A.
通讯作者：
Wilson, Ian A.
影响因子：
64.5
作者：
CATON, AJ;BROWNLEE, GG;GERHARD, W
通讯作者：
GERHARD, W
DOI：
10.1126/science.1234150
发表时间：
2013-05-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jardine J;Julien JP;Menis S;Ota T;Kalyuzhniy O;McGuire A;Sok D;Huang PS;MacPherson S;Jones M;Nieusma T;Mathison J;Baker D;Ward AB;Burton DR;Stamatatos L;Nemazee D;Wilson IA;Schief WR
通讯作者：
Schief WR