Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis.
Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis.
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DOI：
10.1136/bmjopen-2022-061121
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发表时间：
2022-06-28
期刊：
影响因子：
2.9
通讯作者：
Hanna, Timothy P.
中科院分区：
文献类型：
--
作者：
Morrill, Kristin E.;Robles-Morales, Rogelio;Lopez-Pentecost, Melissa;Martinez Portilla, Raigam J.;Saleh, Ahlam A.;Skiba, Meghan B.;Riall, Taylor S.;Austin, Jessica D.;Hirschey, Rachel;Jacobs, Elizabeth T.;Spotleson, Lena;Hanna, Timothy P.
治疗延迟与成年癌症患者死亡风险增加显著相关;然而，与这些延迟相关的因素尚未得到有力的评估。本综述和荟萃分析将评估与五种常见癌症患者治疗延迟相关的因素。将检索科学数据库，包括奥维德MEDLINE、Elsevier Embase、EBSCOhost CINAHL Plus全文、Elsevier Scopus和ProQuest Dissertations and Theses Global，以识别2000年1月至2021年10月期间发表的相关文章。将纳入在美国发表的评价乳腺癌、肺癌、前列腺癌、宫颈癌或结直肠癌成人患者治疗延迟相关因素的研究文章。荟萃分析的主要结局将是根据规定的时间间隔定义的患者、疾病、提供者和系统水平因素的治疗延迟的汇总校正和未校正比值。次要结局将是根据首次治疗的每个癌症部位的平均或中位治疗延迟以及各因素对每个癌症部位汇总平均治疗延迟的影响（通过荟萃回归分析）。定性和混合方法研究的结果将被叙述性地综合。三名审查员将独立筛选检索生成的记录，两名审查员将在达成共识后独立提取数据。将使用标准I2检验评估统计异质性，并将使用漏斗图评估发表偏倚。偏倚风险将由两位作者根据文章的研究设计使用经验证的工具独立评估。不需要正式的伦理批准，因为这项工作是在公开的研究中进行的。本次审查的结果将通过同行评审的科学期刊、学术会议、社交媒体和主要利益攸关方传播。CRD 42021293131。
Treatment delays are significantly associated with increased mortality risk among adult cancer patients; however, factors associated with these delays have not been robustly evaluated. This review and meta-analysis will evaluate factors associated with treatment delays among patients with five common cancers. Scientific databases including Ovid MEDLINE, Elsevier Embase, EBSCOhost CINAHL Plus Full Text, Elsevier Scopus and ProQuest Dissertations and Theses Global will be searched to identify relevant articles published between January 2000 and October 2021. Research articles published in the USA evaluating factors associated with treatment delay among breast, lung, prostate, cervical or colorectal adult cancer patients will be included. The primary outcome of the meta-analysis will be the pooled adjusted and unadjusted odds of treatment delay for patient, disease, provider and system-level factors defined according to specified time intervals. The secondary outcomes will be mean or median treatment delay for each cancer site according to first treatment and the influence of factors on the pooled mean treatment delay for each cancer site (via meta-regression analyses). Results from qualitative and mixed-methods studies will be narratively synthesised. Three reviewers will independently screen records generated from the search and two reviewers will independently extract data following a consensus agreement. Statistical heterogeneity will be assessed with a standard I2 test and funnel plots will be conducted to evaluate publication bias. Risk of bias will be assessed independently by two authors using validated tools according to the article’s study design. Formal ethical approval is not required because the work is being carried out on publicly accessible studies. The findings of this review will be disseminated through a peer-reviewed scientific journal, academic conferences, social media, and key stakeholders. CRD42021293131.
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