Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex.
Advances in Phage Therapy: Targeting the Burkholderia cepacia Complex.
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DOI：
10.3390/v13071331
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发表时间：
2021-07-09
期刊：
影响因子：
--
通讯作者：
Dennis JJ
中科院分区：
文献类型：
--
作者：
Lauman P;Dennis JJ
耐多药细菌病原体的日益流行和全球分布对公共卫生构成迫在眉睫的威胁，并威胁到现代医学的几乎所有方面。特别令人关注但尚未得到充分解决的是洋葱伯克霍尔德菌复合体（Bcc）的成员，这是一组至少20种机会性的、医院传播的且众所周知的耐药性物种，其感染免疫功能低下的患者和患有慢性疾病（包括囊性纤维化（CF）和慢性肉芽肿病（CGD））的患者并引起其发病。抗菌药物耐药性危机的一个潜在解决方案是噬菌体治疗--使用噬菌体治疗细菌感染。尽管噬菌体疗法有着悠久而曲折的历史，但在过去的几十年里，大量的现代研究表明，当通过特定的、科学支持的治疗策略应用时，噬菌体疗法是非常有效的，是一种有希望的对抗耐药和难以治疗的病原体的途径，如BCC。在这篇综述中，我们讨论了Bcc的临床意义，噬菌体治疗的优势，以及噬菌体治疗在过去几十年中取得的理论和临床进展，并将这些概念具体应用于新生的，但不断增长和迅速发展的Bcc噬菌体治疗领域。
The increasing prevalence and worldwide distribution of multidrug-resistant bacterial pathogens is an imminent danger to public health and threatens virtually all aspects of modern medicine. Particularly concerning, yet insufficiently addressed, are the members of the Burkholderia cepacia complex (Bcc), a group of at least twenty opportunistic, hospital-transmitted, and notoriously drug-resistant species, which infect and cause morbidity in patients who are immunocompromised and those afflicted with chronic illnesses, including cystic fibrosis (CF) and chronic granulomatous disease (CGD). One potential solution to the antimicrobial resistance crisis is phage therapy—the use of phages for the treatment of bacterial infections. Although phage therapy has a long and somewhat checkered history, an impressive volume of modern research has been amassed in the past decades to show that when applied through specific, scientifically supported treatment strategies, phage therapy is highly efficacious and is a promising avenue against drug-resistant and difficult-to-treat pathogens, such as the Bcc. In this review, we discuss the clinical significance of the Bcc, the advantages of phage therapy, and the theoretical and clinical advancements made in phage therapy in general over the past decades, and apply these concepts specifically to the nascent, but growing and rapidly developing, field of Bcc phage therapy.
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DOI：
10.1099/00207713-37-2-144
发表时间：
1987-04-01
期刊：
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY
影响因子：
--
作者：
AZEGAMI, K;NISHIYAMA, K;FUKAZAWA, C
通讯作者：
FUKAZAWA, C
影响因子：
11.1
作者：
Boucher, R. C.
通讯作者：
Boucher, R. C.
影响因子：
3.2
作者：
Bick, JA;Dennis, JJ;Leustek, T
通讯作者：
Leustek, T
影响因子：
3.3
作者：
Bach, Evelise;Sant'Anna, Fernando Hayashi;Pereira Passaglia, Luciane Maria
通讯作者：
Pereira Passaglia, Luciane Maria
影响因子：
4.8
作者：
Akturk, Ergun;Oliveira, Hugo;Azeredo, Joana
通讯作者：
Azeredo, Joana