Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients.
Immunohistochemical expression of COX2 and iNOS in bladder cancer and its association with urinary schistosomiasis among Sudanese patients.
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DOI：
10.1186/1750-9378-8-9
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发表时间：
2013-02-15
影响因子：
3.7
通讯作者：
Ahmed HG
中科院分区：
文献类型：
--
作者：
Hassan HE;Mohamed AA;Bakhiet AO;Ahmed HG
本研究的目的是确定膀胱癌中COX 2和iNOS标记物的表达与尿血吸虫病之间是否存在任何关系。应用免疫组化方法检测了155例膀胱癌（87例SCC和68例TCC）和39例良性膀胱炎组织中COX 2和iNOS的表达。194例膀胱癌组织中COX 2和iNOS的阳性表达率分别为71.6%和57.2%。发现COX 2或iNOS表达与膀胱病变（SCC、TCC和膀胱炎）之间的显著正相关（p值= 0.000）。COX 2和iNOS在SCC组、TCC组和膀胱炎组共表达73例（83.9%）、15例（22.1%）和11例（28.2%）。COX 2和iNOS免疫染色与血吸虫卵阳性之间的关系在统计学上确定为P值分别为0.0565和0.1223。在苏丹血吸虫相关膀胱病变患者中，COX 2和iNOS的阳性表达率较高。在苏丹，膀胱癌和尿血吸虫病的高发病率之间可能有很强的关联，因为绝大多数病变对COX 2呈阳性。
The purpose of this study was to determine if any relationship exists between expression of COX2 and iNOS markers and urinary schistosomiasis in bladder cancers. Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis. The overall immune-expressions of COX2 and iNOS were 71.6% and 57.2% respectively, of the 194 bladder lesions. A significant Positive association between COX2 or iNOS expression with bladder lesions (SCC, TCC and cystitis) was found (p.value = 0.000). COX2 and iNOS were co-expressed among 73(83.9%) of SCC, 15(22.1%) of TCC and 11(28.2%) of the cystitis group. The relationship between COX2 and iNOS immunostaining and Schistosomal ova positivity was statistically determined by P values 0.0565 and 0.1223 for Cox2 and iNOS, respectively. There are high rates of positive expression of COX2 and iNOS among Sudanese patients with Schistosomal-related bladder lesions. There might be strong association between high rates of bladder cancers and urinary Schistosomiasis in the Sudan since, the great majority of lesions were positive for COX2.
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影响因子：
8.8
作者：
Jenkins, D. C.;Charles, I. G.;Baylis, S. A.;Lelchuk, R.;Radomski, M. W.;Moncada, S.
通讯作者：
Moncada, S.
影响因子：
6.4
作者：
Salim, Elsayed I.;Morimura, Keiichirou;Wanibuchi, Hideki
通讯作者：
Wanibuchi, Hideki
影响因子：
2
作者：
Singh, Shrawan K.;Wadhwa, Pankaj;Jha, Vivekanand
通讯作者：
Jha, Vivekanand
DOI：
10.3402/ljm.v7i0.14694
发表时间：
2012
期刊：
The Libyan journal of medicine
影响因子：
--
作者：
El Gehani K;Al-Kikhia L;Emaetig F;Syrjänen K;Al-Fituri O;Elzagheid A
通讯作者：
Elzagheid A
影响因子：
4.7
作者：
CHHATWAL, VJS;NGOI, SS;MOOCHHALA, SM
通讯作者：
MOOCHHALA, SM