Frontal neurons modulate memory retrieval across widely varying temporal scales.
Frontal neurons modulate memory retrieval across widely varying temporal scales.
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DOI：
10.1101/lm.036806.114
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发表时间：
2015-06
期刊：
影响因子：
--
通讯作者：
Williams ZM
中科院分区：
文献类型：
--
作者：
Zhang WH;Williams ZM
Once a memory has formed, it is thought to undergo a gradual transition within the brain from short- to long-term storage. This putative process, however, also poses a unique problem to the memory system in that the same learned items must also be retrieved across broadly varying time scales. Here, we find that neurons in the ventrolateral prefrontal cortex (VLPFC) of monkeys, an area interconnected with both temporal and frontal associative neocortical regions, signaled the need to alter between retrieval of memories formed at different times. These signals were most closely related to the time interval between initial learning and later retrieval, and did not correlate with task switch demands, novelty, or behavioral response. Consistent with these physiological findings, focal inactivation of the VLPFC led to a marked degradation in retrieval performance. These findings suggest that the VLPFC plays a necessary regulatory role in retrieving memories over different temporal scales.
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DOI：
10.1523/jneurosci.3793-11.2011
发表时间：
2011-12-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Asaad WF;Eskandar EN
通讯作者：
Eskandar EN
影响因子：
56.9
作者：
Hasegawa, I;Fukushima, T;Miyashita, Y
通讯作者：
Miyashita, Y
影响因子：
16.2
作者：
Asaad, WF;Rainer, G;Miller, EK
通讯作者：
Miller, EK
影响因子：
16.2
作者：
Liston, Conor;Matalon, Shanna;Casey, B. J.
通讯作者：
Casey, B. J.
影响因子：
2.1
作者：
McIntosh, AR
通讯作者：
McIntosh, AR