Interaction between the Tryptophan Hydroxylase Gene and the Serotonin Transporter Gene in Schizophrenia but Not in Bipolar or Unipolar Affective Disorders
Interaction between the Tryptophan Hydroxylase Gene and the Serotonin Transporter Gene in Schizophrenia but Not in Bipolar or Unipolar Affective Disorders
复制标题
色氨酸羟化酶基因与血清素转运蛋白基因在精神分裂症中的相互作用，但在双相或单相情感障碍中则不然
作者：
J. Chotai;A. Serretti;C. Lorenzi
越来越多的关注被给予，以确定可能的组合基因相关的特定的临床表型。在我们的814例患者中，包括114例精神分裂症，416例双相情感障碍和284例单相情感障碍，我们研究了色氨酸羟化酶（TPH），5-羟色胺转运蛋白（5-HTTLPR）和多巴胺受体（DRD 4）基因之间的相互作用与五个主要的精神病学评分。TPH和5-HTTLPR基因之间存在显著的互作。随着5-HTTLPR短等位基因数量的增加，妄想、混乱和阴性症状的评分在具有TPH基因型AA的受试者中显著降低，但在具有TPH基因型AC的受试者中升高，产生AA × ll和AC × ss组合的最高评分。由于在精神分裂症受试者中仅在妄想、混乱和阴性症状上得分较高，而在兴奋和抑郁上得分较低，因此我们在三种诊断类别和对照组之间进行了TPH × 5-HTTLPR基因型分布的比较。精神分裂症患者TPH × 5-HTTLPR基因型组合的分布与241例对照组、单相或双相患者相比有显著性差异，AA × ll和AC × ss的频率显著较高。因此，TPH和5-HTTLPR基因之间的相互作用构成了精神分裂症的易感性，从而产生了明显的关系之间的主要精神病学评分和基因型组合的样本，通过合并精神分裂症与其他诊断类别。
Increasing focus is being given to identify possible combinations of genes related to specific clinical phenotypes. In our sample of 814 patients comprising 114 with schizophrenia, 416 with bipolar affective disorder and 284 with unipolar affective disorder, we studied interactions between the tryptophan hydroxylase (TPH), the serotonin transporter (5-HTTLPR), and the dopamine receptor (DRD4) genes in relation to five major psychiatric symptomatology scores. There was significant interaction between the TPH and the 5-HTTLPR genes. With an increasing number of short (s) alleles of 5-HTTLPR, the scores for delusions, disorganization and negative symptoms were significantly decreasing among subjects having the TPH genotype AA but increasing among subjects having the TPH genotype AC, yielding the highest scores for the combinations AA × ll and AC × ss. Since high scores on just delusions, disorganization and negative symptoms but low scores on excitement and depression were found among subjects with schizophrenia, we conducted comparisons among the three diagnostic categories and controls as regards the combined TPH × 5-HTTLPR genotype distribution. Schizophrenia subjects had a significantly different distribution of the genotype combination for TPH × 5-HTTLPR as compared to 241 controls or to unipolar or bipolar subjects, and had significantly higher frequencies of AA × ll and of AC × ss. Thus, an interaction between TPH and 5-HTTLPR genes constitutes susceptibility to schizophrenia, thereby yielding apparent relationships between the major psychiatric symptomatology scores and genotype combinations in samples that are obtained by pooling schizophrenia with other diagnostic categories.
影响因子：
17.7
作者：
Faraone, SV;Doyle, AE;Biederman, J
通讯作者：
Biederman, J