1H-MRS at 4 tesla in minimally treated early schizophrenia.
1H-MRS at 4 tesla in minimally treated early schizophrenia.
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DOI：
10.1038/mp.2009.121
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发表时间：
2010-06
影响因子：
11
通讯作者：
中科院分区：
文献类型：
--
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我们研究了抗精神病药物治疗前后精神分裂症早期前扣带（AC）中谷氨酸相关的神经元功能障碍。采用单体素质子磁共振波谱（1H-MRS）对14例轻度治疗精神分裂症患者和10名健康受试者进行脑皮层、额叶白质和丘脑4 t时的检测，测定n -乙酰天冬氨酸（NAA）、谷氨酸（Glu）、谷氨酰胺（Gln）浓度和Gln/Glu比值，并校正部分组织体积。患者按照特定的算法接受抗精神病药物治疗，并在1、6和12个月后重复1H-MRS。基线NAA （P = 0.074）和Gln/Glu （P = 0.028）存在组×区相互作用：精神分裂症患者治疗前AC NAA较低（P = 0.045）， Gln/Glu较高（P = 0.006）。精神分裂症患者AC Gln/Glu与AC NAA呈负相关（P = 0.0009），对照组AC NAA与AC Gln/Glu呈负相关（P = 0.92）。在抗精神病药物治疗后，NAA， Gln/Glu或任何其他代谢物在任何研究区域都没有进一步的变化。我们得出结论，在疾病早期，精神分裂症患者已经表现出谷氨酸代谢异常和NAA减少，这与谷氨酸相关的兴奋性毒性一致。
We investigated glutamate-related neuronal dysfunction in the anterior cingulate (AC) early in schizophrenia before and after antipsychotic treatment. A total of 14 minimally treated schizophrenia patients and 10 healthy subjects were studied with single-voxel proton magnetic resonance spectroscopy (1H-MRS) of the AC, frontal white matter and thalamus at 4 T. Concentrations of N-acetylaspartate (NAA), glutamate (Glu), glutamine (Gln) and Gln/Glu ratios were determined and corrected for the partial tissue volume. Patients were treated with antipsychotic medication following a specific algorithm and 1H-MRS was repeated after 1, 6 and 12 months. There were group × region interactions for baseline NAA (P = 0.074) and Gln/Glu (P = 0.028): schizophrenia subjects had lower NAA (P = 0.045) and higher Gln/Glu (P = 0.006) in the AC before treatment. In addition, AC Gln/Glu was inversely related to AC NAA in the schizophrenia (P = 0.0009) but not in the control group (P = 0.92). Following antipsychotic treatment, there were no further changes in NAA, Gln/Glu or any of the other metabolites in any of the regions studied. We conclude that early in the illness, schizophrenia patients already show abnormalities in glutamatergic metabolism and reductions in NAA consistent with glutamate-related excitotoxicity.
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影响因子：
7.6
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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作者：
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通讯作者：
Haroutunian, V
DOI：
10.1098/rstb.1999.0471
发表时间：
1999-07-29
影响因子：
6.3
作者：
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通讯作者：
Pellerin, L