Glycomaterials to Investigate the Functional Role of Aberrant Glycosylation in Glioblastoma.
Glycomaterials to Investigate the Functional Role of Aberrant Glycosylation in Glioblastoma.
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DOI：
10.1002/adhm.202101956
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发表时间：
2022-03
影响因子：
10
通讯作者：
Karumbaiah L
中科院分区：
文献类型：
--
作者：
Tondepu C;Karumbaiah L
胶质母细胞瘤 (GBM) 是一种 IV 期星形细胞瘤，诊断和治疗后的生存率仅为约 10 个月。 GBM 的高度侵袭能力及其逃避治疗挑战的能力是导致总体生存率较低的关键因素。虽然目前的治疗旨在针对癌细胞本身，但他们没有考虑到 GBM 肿瘤微环境 (TME) 在促进肿瘤进展和治疗耐药方面发挥的重要作用。 GBM 肿瘤糖萼和富含聚糖的细胞外基质 (ECM) 是 TME 的重要组成部分，但作为治疗靶点却很少受到关注。 GBM TME 中大量异常修饰的聚糖介导肿瘤生长、侵袭、治疗耐药和免疫抑制。在这里，我们概述了 GBM 中异常聚糖修饰的情况，并讨论了三维糖材料的设计和实用性，作为评估聚糖介导的 GBM 进展和治疗效果的工具。开发针对 TME 中聚糖的替代策略可能会揭示限制肿瘤生长和增强肿瘤靶向治疗功效的更广泛机制。脑肿瘤微环境中异常修饰的细胞外聚糖介导与其他细胞和可溶性因子的相互作用，从而促进肿瘤进展并促进免疫逃逸。这篇综述文章详细概述了 GBM 中异常修饰的聚糖结构，这些结构有助于肿瘤侵袭、抵抗和免疫抑制。本文还概述了将生理相关聚糖纳入 3D 糖材料结构中的合理设计策略，该结构可用于评估 GBM 进展和治疗反应。
Glioblastoma (GBM) is a stage IV astrocytoma that carries a dismal survival rate of ~10 months post-diagnosis and treatment. The highly invasive capacity of GBM and its ability to to escape therapeutic challenges are key factors contributing to the poor overall survival rate. While current treatments aim to target the cancer cell itself, they fail to consider the significant role that the GBM tumor microenvironment (TME) plays in promoting tumor progression and therapeutic resistance. The GBM tumor glycocalyx and glycan-rich extracellular matrix (ECM), which are important constituents of the TME have received little attention as therapeutic targets. A wide array of aberrantly modified glycans in the GBM TME mediate tumor growth, invasion, therapeutic resistance, and immunosuppression. Here, we provide an overview of the landscape of aberrant glycan modifications in GBM, and discuss the design and utility of three-dimensional glycomaterials as a tool to evaluate glycan mediated GBM progression and therapeutic efficacy. The development of alternative strategies to target glycans in the TME can potentially unveil broader mechanisms of restricting tumor growth and enhancing the efficacy of tumor-targeting therapeutics. Aberrantly modified extracellular glycans in the brain tumor microenvironment mediate interactions with other cells and soluble factors to promote tumor progression and facilitate immune escape. This review article provides a detailed overview of the landscape of aberrantly modified glycan structures in GBM, which contribute to tumor invasion, resistance, and immunosuppression. The article also provides an overview of rational design strategies to incorporate physiologically relevant glycans in 3D glycomaterial constructs that can be employed to evaluate GBM progression and treatment response.
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影响因子：
11.2
作者：
Bonavia R;Inda MM;Cavenee WK;Furnari FB
通讯作者：
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Wurdinger T
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