Inhibition of cancer cell invasion and metastasis by genistein.
Inhibition of cancer cell invasion and metastasis by genistein.
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DOI：
10.1007/s10555-010-9238-z
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发表时间：
2010-09
影响因子：
9.2
通讯作者：
Bergan, Raymond C.
中科院分区：
文献类型：
--
作者：
Pavese, Janet M.;Farmer, Rebecca L.;Bergan, Raymond C.
染料木黄酮是一种小的生物活性类黄酮，在大豆中含量很高。这种重要的化合物具有多种生物活性，但它最为人所知的是其抑制癌症进展的能力。特别地，染料木黄酮已经成为癌症转移的重要抑制剂。在一些以人群为基础的研究中，饮食中摄入染料木黄酮与转移性癌症的发病率降低有关。已经进行了广泛的研究，以确定染料木黄酮的抗转移活性的分子机制，结果表明，这种小分子具有显着的抑制活性，在几乎每一个步骤的转移级联。报道已经证明，在高浓度下，染料木黄酮可以抑制与原发性肿瘤生长和凋亡有关的几种蛋白质，包括细胞周期蛋白类细胞周期调节剂和Akt蛋白家族。在与通过饮食摄入达到的浓度相似的较低浓度下，染料木黄酮可以通过多种机制（包括转化生长因子（TGF）-β信号通路）抑制癌细胞脱离、迁移和侵袭的促转移过程。在体内动物研究和早期人类临床试验中，已经证实了几个体外研究结果，证明染料木黄酮既可以抑制人类癌症转移，也可以分别调节人类转移潜能的标志物。在此，我们讨论了染料木黄酮调节转移级联反应各个步骤的多种机制，并强调了这种天然产物作为一种有前途的转移治疗抑制剂的潜力。
Genistein is a small, biologically active flavonoid that is found in high amounts in soy. This important compound possesses a wide variety of biological activities, but it is best known for its ability to inhibit cancer progression. In particular, genistein has emerged as an important inhibitor of cancer metastasis. Consumption of genistein in the diet has been linked to decreased rates of metastatic cancer in a number of population-based studies. Extensive investigations have been performed to determine the molecular mechanisms underlying genistein’s antimetastatic activity, with results indicating that this small molecule has significant inhibitory activity at nearly every step of the metastatic cascade. Reports have demonstrated that, at high concentrations, genistein can inhibit several proteins involved with primary tumor growth and apoptosis, including the cyclin class of cell cycle regulators and the Akt family of proteins. At lower concentrations that are similar to those achieved through dietary consumption, genistein can inhibit the prometastatic processes of cancer cell detachment, migration, and invasion through a variety of mechanisms, including the transforming growth factor (TGF)-β signaling pathway. Several in vitro findings have been corroborated in both in vivo animal studies and in early-phase human clinical trials, demonstrating that genistein can both inhibit human cancer metastasis and also modulate markers of metastatic potential in humans, respectively. Herein, we discuss the variety of mechanisms by which genistein regulates individual steps of the metastatic cascade and highlight the potential of this natural product as a promising therapeutic inhibitor of metastasis.
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DOI：
10.1111/j.1349-7006.2000.tb00928.x
发表时间：
2000-02-01
期刊：
JAPANESE JOURNAL OF CANCER RESEARCH
影响因子：
--
作者：
Choi, YH;Lee, WH;Zhang, LJ
通讯作者：
Zhang, LJ
影响因子：
3.8
作者：
Bobe, Gerd;Sansbury, Leah B.;Lanza, Elaine
通讯作者：
Lanza, Elaine
影响因子：
7.1
作者：
Bloedon, LT;Jeffcoat, AR;Zeisel, SH
通讯作者：
Zeisel, SH
影响因子：
4
作者：
Bergan, R;Kyle, E;Neckers, L
通讯作者：
Neckers, L
影响因子：
4.8
作者：
CHEN, HC;APPEDDU, PA;GUAN, JL
通讯作者：
GUAN, JL