A Quantitative Model for the Measurement of Cerebral Vascular Extraction Fraction In vivo following Intravenous Injection: Simulation Studies
A Quantitative Model for the Measurement of Cerebral Vascular Extraction Fraction In vivo following Intravenous Injection: Simulation Studies
复制标题
静脉注射后体内脑血管提取分数测量的定量模型：模拟研究
DOI：
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发表时间：
1984
影响因子：
6.3
通讯作者：
A. Gilson
中科院分区：
文献类型：
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作者：
S. Takagi;P. Kenny;A. Gilson
本文提出了一种数学方法，通过该方法可以定量地测量静脉注射的限流和限扩散示踪剂的脑血管提取分数。需要连续注射三种示踪剂：测试示踪剂，如15 O标记水;作为参考示踪剂和流动示踪剂的完全扩散示踪剂;以及脑血容量（CBV）示踪剂。需要动脉示踪剂浓度曲线和试验和参考示踪剂的总积分头数以及CBF和CBV值来计算提取分数。人头计数和动脉曲线之间不需要校准。不需要头部和动脉活动的衰变校正，因为同位素衰变明确包括在方程中。未提取的测试示踪剂的影响可以被校正。模拟研究表明，计算的提取分数值对CBF、CBV、分配系数、测量时间变化或动脉和头部数据之间的时移效应的测量误差不敏感。如果大脑中存在两种不同组织的混合，则计算出的提取分数值接近通过组织的相对重量的提取分数的加权平均值。它的结论是，它是可能的，将这种方法应用于人类研究与正电子发射断层扫描仪和动物研究与外部符合探测器。
A mathematical method has been developed by which the cerebral vascular extraction fraction of flow- and diffusion-limited tracers injected intravenously can be measured quantitatively. Successive injections of three tracers are required: a test tracer such as 15O-labeled water; a completely diffusible tracer as a reference tracer and also as a flow tracer; and a tracer for cerebral blood volume (CBV). The arterial tracer concentration curves and total integrated head counts of the test and reference tracers, as well as CBF and CBV values, are required to calculate the extraction fraction. No calibration is required between the head counts and arterial curves. No decay correction of the head and arterial activity is required, because isotopic decay is explicitly included in the equation. The effect of nonextracted test tracer can be corrected. Simulation studies have shown that the calculated extraction fraction values are not sensitive to measurement error in CBF, CBV, partition coefficient, change in measurement time, or time shift effect between the arterial and head data. If there is mixing of two different tissues in the brain, the calculated extraction fraction values are close to the weighted mean values of extraction fraction by relative weight of the tissues. It is concluded that it is possible to apply this method to human studies with a positron emission tomograph scanner and to animal studies with external coincidence detectors.
DOI：
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发表时间：
2006
期刊：
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影响因子：
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作者：
M. Mintun;M. Raichle;W. Martin
通讯作者：
M. Mintun;M. Raichle;W. Martin