Intact but less accessible phonetic representations in adults with dyslexia.

Intact but less accessible phonetic representations in adults with dyslexia.
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DOI:
10.1126/science.1244333
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发表时间:
2013-12-06
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Ghesquière P
Ghesquière P
中科院分区:
其他
文献类型:
--
作者:
Boets B;Op de Beeck HP;Vandermosten M;Scott SK;Gillebert CR;Mantini D;Bulthé J;Sunaert S;Wouters J;Ghesquière P

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诵读困难是一种严重的和持续的阅读和拼写障碍所造成的损害,以操纵语音。在这里,我们将联合收割机功能磁共振脑成像与多体素模式分析和功能和结构连接分析相结合,以解开阅读障碍者的语音缺陷是由语音表征质量差还是难以访问完整的语音表征造成的。我们发现,语音表征主办双边在初级和次级听觉皮层,他们的神经质量是完整的成人阅读障碍。然而,功能和结构之间的连接双侧听觉皮层和左额下回(一个地区参与了更高层次的语音处理)显着阻碍诵读困难症,这表明缺乏访问,否则完整的语音表示。
Dyslexia is a severe and persistent reading and spelling disorder caused by impairment to manipulate speech sounds. Here, we combine functional magnetic resonance brain imaging with multi-voxel pattern analysis and functional and structural connectivity analysis to disentangle whether dyslexics’ phonological deficits are caused by poor quality of the phonetic representations or by difficulties in accessing intact phonetic representations. We show that phonetic representations are hosted bilaterally in primary and secondary auditory cortices, and that their neural quality is intact in adults with dyslexia. However, the functional and structural connectivity between bilateral auditory cortices and left inferior frontal gyrus (a region involved in higher-level phonological processing) is significantly hampered in dyslexics, suggesting deficient access to otherwise intact phonetic representations.
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发表时间: 2011-06-01
期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
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