Elevated plasma trimethylamine-N-oxide levels are associated with diabetic retinopathy.
Elevated plasma trimethylamine-N-oxide levels are associated with diabetic retinopathy.
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血浆三甲胺 N 氧化物水平升高与糖尿病视网膜病变相关
DOI：
10.1007/s00592-020-01610-9
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发表时间：
2021-03
影响因子：
3.8
通讯作者：
Lu P
中科院分区：
文献类型：
--
作者：
Liu W;Wang C;Xia Y;Xia W;Liu G;Ren C;Gu Y;Li X;Lu P
确定血浆三甲胺-N-氧化物 (TMAO) 水平与糖尿病视网膜病变 (DR) 几率之间的关系。进行了一项横断面研究。血液样本取自 122 名患有或不患有 DR 的 2 型糖尿病 (T2DM) 患者。进行多变量逻辑回归分析以确定血浆 TMAO 与 DR 之间的关联。血浆TMAO的诊断价值通过受试者工作特征曲线下面积（AUROC）和综合辨别改善（IDI）来评估。在T2DM患者中，DR患者血浆TMAO水平显着高于非DR患者（P = 0.001）。随着 TMAO 的对数 (ln) 变换每标准差 (SD) 增加，出现 DR 的可能性就更高 [比值比 (OR) = 2.31； P = 0.005]。随着每 SD 转化 TMAO 的增加，DR 的严重程度更有可能变得更严重（OR = 2.05；P = 0.004）。在诊断模型中，TMAO的添加有助于AUROC从0.646改善至0.734（P = 0.043），IDI为10.7%（P < 0.001）。血浆 TMAO 水平升高与 T2DM 患者 DR 的发生率较高和严重程度较差相关，需要进一步研究这种关联的因果关系。
To determine the relationship between plasma levels of trimethylamine-N-oxide (TMAO) and odds of diabetic retinopathy (DR). A cross-sectional study was conducted. Blood samples were obtained from 122 type 2 diabetes mellitus (T2DM) patients with or without DR. Multivariable logistic regression analyses were performed to identify the association between plasma TMAO and DR. The diagnostic value of plasma TMAO was assessed by the area under the receiver operating characteristic curve (AUROC) and integrated discrimination improvement (IDI). In the T2DM patients, plasma levels of TMAO were significantly higher in patients with DR compared with those without DR (P = 0.001). As logarithmic (ln) transformation of TMAO increased per standard deviation (SD), there was higher probability to have DR [odds ratio (OR) = 2.31; P = 0.005]. As ln-transformed TMAO increased per SD, the severity of DR was more likely to get worse (OR = 2.05; P = 0.004). In the diagnostic model, the addition of TMAO contributed to the improvement in AUROC from 0.646 to 0.734 (P = 0.043), and the IDI was 10.7% (P < 0.001). Elevated levels of plasma TMAO were associated with higher odds and worse severity of DR in T2DM patients, and further investigation is required for the causality of this association.
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影响因子：
24.5
作者：
Heianza Y;Sun D;Li X;DiDonato JA;Bray GA;Sacks FM;Qi L
通讯作者：
Qi L
影响因子：
5.6
作者：
Singh, Gurinder Bir;Zhang, Yang;Koka, Saisudha
通讯作者：
Koka, Saisudha
DOI：
10.1161/atvbaha.119.312592
发表时间：
2019-06-01
影响因子：
8.7
作者：
Shih, Diana M.;Zhu, Weifei;Lusis, Aldons J.
通讯作者：
Lusis, Aldons J.
影响因子：
82.9
作者：
Roberts AB;Gu X;Buffa JA;Hurd AG;Wang Z;Zhu W;Gupta N;Skye SM;Cody DB;Levison BS;Barrington WT;Russell MW;Reed JM;Duzan A;Lang JM;Fu X;Li L;Myers AJ;Rachakonda S;DiDonato JA;Brown JM;Gogonea V;Lusis AJ;Garcia-Garcia JC;Hazen SL
通讯作者：
Hazen SL
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)