COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions.
COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions.
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COMT-Val158Met 多态性调节健康个体幻听和颞叶灰质体积的抗精神病作用——症状缓解，伴随着令人担忧的体积减少
DOI：
10.1007/s11682-019-00043-5
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发表时间：
2020-10
影响因子：
3.2
通讯作者：
Zhou C
中科院分区：
文献类型：
--
作者：
Zhuo C;Cheng L;Li G;Xu Y;Jing R;Li S;Zhang L;Lin X;Zhou C
精神分裂症患者的幻听（AVH）调查因精神症状而变得复杂。研究患有 AVH (H-AVH) 的健康个体可以消除此类混杂因素。本研究的目的是探讨抗精神病药物治疗对 H-AVH 受试者的 AVH 和灰质体积 (GMV) 的影响，以及这些影响是否受到 COMT-Val158Met 基因型的影响。对 42 名 H-AVH 受试者和 42 名匹配的健康对照 (HC) 完成了磁共振成像 (MRI) 和基因分型研究。 COMT-Met/Met纯合子(第158密码子)被鉴定为COMT-Met基因型； COMT-Met/Val杂合子和COMT-Val/Val纯合子被鉴定为COMT-Val基因型。通过双样本 t 检验比较各组之间的数据（H-AVH 与 HC，以及基因型之间）。 H-AVH COMT-Met 组对抗精神病药物治疗的反应比 H-AVH COMT-Val 组更强 (p < 0.001)。相对于各自基因型匹配的 HC 组，两个 H-AVH 基因型组在治疗后均表现出颞叶 GMV 降低。 H-AVH 受试者的抗精神病治疗效果受到 COMT-Val158Met 基因型的影响，并与广泛的 GMV 降低相关。这些发现为进一步探索 AVH 的治疗靶点提供了线索。然而，治疗相关的 GMV 降低引起了人们对 H-AVH 受试者使用抗精神病药物的担忧。
Investigation of auditory verbal hallucinations (AVHs) in schizophrenics is complicated by psychiatric symptoms. Investigating healthy individuals with AVHs (H-AVHs) can obviate such confounding factors. The objective of this study was to explore the effects of antipsychotic treatment on AVHs and gray matter volumes (GMVs) in H-AVH subjects and whether such are effects are influenced by COMT-Val158Met genotype. Magnetic resonance imaging (MRI) and genotyping studies were completed for 42 H-AVH subjects and 42 well-matched healthy controls (HCs). COMT-Met/Met homozygotes (158th codon) were identified as COMT-Met genotype; COMT-Met/Val heterozygotes and COMT-Val/Val homozygotes were identified as COMT-Val genotype. Data were compared across groups (H-AVH vs. HC, and between genotypes) with two-sample t-tests. The H-AVH COMT-Met group showed a stronger response to antipsychotic treatment than the H-AVH COMT-Val group (p 0.001). Both H-AVH genotype groups exhibited temporal lobe GMV reductions after treatment, and relative to their respective genotype-matched HC groups. Antipsychotic treatment effects in H-AVH subjects were influenced by COMT-Val158Met genotype and associated with widespread GMV reductions. These findings provide clues for further exploration of treatment targets for AVHs. Treatment associated GMV reductions, however, raise concerns about use of antipsychotics in H-AVH subjects.
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DOI：
10.1176/appi.ajp.2013.12050674
发表时间：
2013-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen NC;Liu D;Ziebell S;Vora A;Ho BC
通讯作者：
Ho BC
影响因子：
10.5
作者：
Johns, LC;Cannon, M;Meltzer, H
通讯作者：
Meltzer, H
影响因子：
14.5
作者：
Alderson-Day, Ben;Lima, Cesar F.;Scott, Sophie K.
通讯作者：
Scott, Sophie K.
影响因子：
6.6
作者：
Dollfus, Sonia;Jaafari, Nemat;Etard, Olivier
通讯作者：
Etard, Olivier
影响因子：
2.9
作者：
de Leede-Smith S;Barkus E
通讯作者：
Barkus E