Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs.
Estrogen Receptor Alpha as a Mediator of Life-History Trade-offs.
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雌激素受体α作为生活史权衡的中介。
DOI：
10.1093/icb/icv005
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发表时间：
2015
影响因子：
2.6
通讯作者：
Zinzow-Kramer,WendyM
中科院分区：
文献类型：
--
作者：
Maney,DonnaL;Horton,BrentM;Zinzow-Kramer,WendyM
竞争策略和亲代策略之间的权衡通常是由性类固醇调节的。因此，类固醇信号传导和代谢的机制可能作为破坏性选择的目标，导致不同的行为表型。白喉麻雀表现出两种不同的颜色变化，它们在竞争行为和亲代行为上都有所不同；白条纹鸟（WS）的鸣叫声更有领地性，而棕条纹鸟（TS）则更经常为雏鸟提供食物。虽然WS鸟类的血浆睾酮(T)和雌二醇水平高于TS鸟类，但实验中这些激素的平衡并不能消除歌唱中形态的差异。雌性激素受体α (ERα)的基因在染色体重排中被捕获，这种基因只在WS鸟类中发现。我们最近发现，该基因的表达在不同的变体之间是不同的，可能会导致行为多态性。首先，ERα启动子区域包含影响体外转录效率的固定多态性。其次，在自由生活的种群中，ERα的局部表达强烈依赖于形态，并预测了领土鸣叫和亲代供给。ERα的差异表达在内侧杏仁核尤为显著；WS鸟类的ERα mRNA是TS鸟类的3倍。这种差异在非繁殖季节持续存在，并且不受外源T处理的影响。最后，通过RNA-seq生成的初步数据证实，ERα在MeA中的表达存在差异，并与领土歌唱相关。总之，这些结果表明，ERα可能是破坏性选择的目标，从而导致替代行为策略。我们未来的方向包括对ERα启动子区域进行更详细的分析，以确定差异表达的分子基础，以及基因网络分析，以识别与ERα相关的基因。
Trade-offs between competitive and parental strategies often are mediated by sex steroids. The mechanisms underlying steroid signaling and metabolism may therefore serve as targets of disruptive selection that leads to alternative behavioral phenotypes. White-throated sparrows exhibit two color morphs that differ in both competitive and parental behavior; white-striped (WS) birds engage in more territorial singing, whereas tan-striped (TS) birds provision nestlings more often. Although WS birds have higher levels of plasma testosterone (T) and estradiol than do TS birds, experimental equalization of these hormones does not abolish morph differences in singing. Neural sensitivity to sex steroids may differ between the morphs because the gene for estrogen receptor alpha (ERα) has been captured by a chromosomal rearrangement found only in the WS birds. We recently showed that expression of this gene differs between the morphs and may drive the behavioral polymorphism. First, the ERα promoter region contains fixed polymorphisms that affect transcription efficiencyin vitro. Second, in a free-living population, local expression of ERα depends strongly on morph and predicts both territorial singing and parental provisioning. Differential ERα expression is particularly striking in the medial amygdala; WS birds have three times more ERα mRNA than do TS birds. This difference persists during the non-breeding season and is unaffected by exogenous T treatment. Finally, preliminary data generated by RNA-seq confirm that ERα expression in MeA is both differentially expressed and correlated with territorial singing. Together, these results suggest that ERα may be a target of disruptive selection that leads to alternative behavioral strategies. Our future directions include a more detailed analysis of the ERα promoter regions to determine the molecular basis of differential expression as well as gene network analyses to identify genes connected to ERα.
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野生雄性歌麻雀的脑芳香酶、5α-还原酶和 5β-还原酶随季节变化：与攻击性和性行为的关系。
DOI：
10.1002/neu.10225
发表时间：
2003
期刊：
Journal of neurobiology
影响因子：
--
作者：
Soma,KiranK;Schlinger,BarneyA;Wingfield,JohnC;Saldanha,ColinJ
通讯作者：
Saldanha,ColinJ
影响因子：
64.8
作者：
Wolf, Max;van Doorn, G. Sander;Weissing, Franz J.
通讯作者：
Weissing, Franz J.
影响因子：
2.6
作者：
Ketterson, Ellen D.;Atwell, Jonathan W.;McGlothlin, Joel W.
通讯作者：
McGlothlin, Joel W.
影响因子：
3.5
作者：
Fleming, AS;Corter, C;Steiner, M
通讯作者：
Steiner, M
白喉麻雀冬季群体的社会地位、激素循环水平和食物竞争
DOI：
--
发表时间：
1988
期刊：
影响因子：
--
作者：
H. Schwabl;M. Ramenofsky;I. Schwabl;D. Farner;J. Wingfield
通讯作者：
J. Wingfield