Cytokine polymorphisms are associated with fatigue in adults living with HIV/AIDS.
Cytokine polymorphisms are associated with fatigue in adults living with HIV/AIDS.
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DOI：
10.1016/j.bbi.2014.02.017
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发表时间：
2014-08
影响因子：
15.1
通讯作者：
Aouizerat, Bradley E.
中科院分区：
文献类型：
--
作者：
Lee, Kathryn A.;Gay, Caryl L.;Lerdal, Anners;Pullinger, Clive R.;Aouizerat, Bradley E.
在成年人中，疲劳与炎症和细胞因子活性有关，但这种关系尚未在感染艾滋病毒的成年人中得到评估。以前已经在成年艾滋病毒/艾滋病患者中发现了疲劳的昼夜模式。因此，本研究的目的是描述这些疲劳模式与细胞因子血浆浓度和基因多态性的关系。为了方便起见，317名成年艾滋病毒/艾滋病感染者连续三天早晚完成了一项疲劳测量；报告早晚疲劳程度较低（n=110）或早晚疲劳程度较高（n=114）的参与者被纳入分析，最终样本为224名成年人（151名男性，55名女性，18名变性人）。分析血浆细胞因子，对参与细胞因子信号传导的干扰素- γ (IFNG)、IFNG受体1 （IFNGR1）、白细胞介素（IL）、B细胞kappa轻多肽基因增强子核因子（NFKB-1和-2）、肿瘤坏死因子α (TNFA)等15个候选基因进行基因分型。人口统计学和临床变量被评估为潜在的协变量。控制了祖先和自我报告的种族/民族和性别的基因组估计，高度疲劳模式与五个单核苷酸多态性（snp）相关：IL1B rs1071676和rs1143627， IL4 rs2243274， TNFA rs1800683和rs1041981。il - 1b和TNFA多态性分别与血浆IL-1β或tnf - α水平无关。这项研究加强了炎症和疲劳之间联系的证据。在这一慢性疾病人群中，与高水平早晚疲劳相关的细胞因子多态性为未来个性化医学干预研究提供了方向。
Fatigue has been associated with inflammation and cytokine activity among adults, but this relationship has not been evaluated among adults living with HIV. Diurnal patterns of fatigue have been previously identified in adults with HIV/AIDS. Thus, the purpose of this study was to describe these fatigue patterns in relation to cytokine plasma concentrations and gene polymorphisms. A convenience sample of 317 adults living with HIV/AIDS completed a measure of fatigue in the morning and evening for three consecutive days; participants reporting low levels of both morning and evening fatigue (n=110) or high levels of fatigue in the morning and evening (n=114) were included in the analysis, resulting in a final sample of 224 adults (151 men, 55 women, and 18 transgender). Plasma cytokines were analyzed, and genotyping was conducted for 15 candidate genes involved in cytokine signaling: interferon-gamma (IFNG), IFNG receptor 1 (IFNGR1), interleukins (IL), nuclear factor of kappa light polypeptide gene enhancer in B cells (NFKB-1 and -2), and tumor necrosis factor alpha (TNFA). Demographic and clinical variables were evaluated as potential covariates. Controlling for genomic estimates of ancestry and self-reported race/ethnicity and gender, the high fatigue pattern was associated with five single nucleotide polymorphisms (SNPs): IL1B rs1071676 and rs1143627, IL4 rs2243274, and TNFA rs1800683 and rs1041981. The IL1B and TNFA polymorphisms were not associated with plasma levels of IL-1β or TNFα, respectively. This study strengthens the evidence for an association between inflammation and fatigue. In this chronic illness population, the cytokine polymorphisms associated with high levels of morning and evening fatigue provide direction for future personalized medicine intervention research.
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影响因子：
4.2
作者：
Lerdal, Anners;Gay, Caryl L.;Lee, Kathryn A.
通讯作者：
Lee, Kathryn A.
影响因子：
45.3
作者：
Bower, Julienne E.;Ganz, Patricia A.;Cole, Steven W.
通讯作者：
Cole, Steven W.
影响因子：
3.1
作者：
Inagaki, Masatoshi;Akechi, Tatsuo;Uchitomi, Yosuke
通讯作者：
Uchitomi, Yosuke
DOI：
10.1007/s00432-003-0540-9
发表时间：
2004-06-01
影响因子：
3.6
作者：
Geinitz, H;Zimmermann, FB;Molls, M
通讯作者：
Molls, M
影响因子：
15.1
作者：
Jim, Heather S. L.;Park, Jong Y.;Permuth-Wey, Jennifer;Rincon, Maria A.;Phillips, Kristin M.;Small, Brent J.;Jacobsen, Paul B.
通讯作者：
Jacobsen, Paul B.