Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings.
Genetic predictors of fatigue in prostate cancer patients treated with androgen deprivation therapy: preliminary findings.
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DOI：
10.1016/j.bbi.2012.03.001
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发表时间：
2012-10
影响因子：
15.1
通讯作者：
Jacobsen, Paul B.
中科院分区：
文献类型：
--
作者：
Jim, Heather S. L.;Park, Jong Y.;Permuth-Wey, Jennifer;Rincon, Maria A.;Phillips, Kristin M.;Small, Brent J.;Jacobsen, Paul B.
疲劳是前列腺癌雄激素剥夺治疗（ADT）常见的令人痛苦的副作用。本研究的目的是研究ADT开始后疲劳变化与三种促炎细胞因子基因的单核苷酸多态性（snp）之间的关系：白细胞介素-1 β (IL1B)、白细胞介素-6 （IL6）和肿瘤坏死因子α (TNFA)。作为一项更大的研究的一部分，在ADT开始之前招募了前列腺癌患者（n=53）。在招募和ADT开始后6个月评估疲劳。从基线抽取的血液中提取DNA。IL6-174 (rs1800795) G/C或C/C基因型患者在疲劳侵入性、频率和持续时间方面比G/G基因型患者表现出更大的增加（p值≤0.05），尽管在模型中纳入年龄、种族和基线抑郁症状减弱了这些关系（p值≤0.09）。TNFA-308 (rs1800629) G/A基因型患者的疲劳严重程度明显高于G/G基因型患者（p=0.02）。IL1B-511 （rs16944）基因型对疲劳变化无显著预测作用（p值>0.46）。与变异数较少的患者相比，变异数较多的患者在疲劳持续时间和干扰方面表现出更大的增加（p值≤0.02）。接受ADT治疗的前列腺癌患者携带il - 6和TNFA基因的变异等位基因，容易产生高度疲劳。这些初步数据支持遗传变异在继发于ADT的癌症相关疲劳发展中的作用。研究结果与开发个性化癌症治疗方法的尝试有关。
Fatigue is a common and distressing side effect of androgen deprivation therapy (ADT) for prostate cancer. The goal of the current study was to examine the relationship between changes in fatigue following initiation of ADT and single nucleotide polymorphisms (SNPs) in three pro-inflammatory cytokine genes: interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor alpha (TNFA). As part of a larger study, men with prostate cancer (n=53) were recruited prior to initiation of ADT. Fatigue was assessed at recruitment and six months after initiation of ADT. DNA was extracted from blood drawn at baseline. Patients with the IL6-174 (rs1800795) G/C or C/C genotype displayed greater increases in fatigue intrusiveness, frequency, and duration than the G/G genotype (p values≤0.05), although inclusion of age, race, and baseline depressive symptomatology in the model attenuated these relationships (p values≤0.09). Patients with the TNFA-308 (rs1800629) G/A genotype showed greater increases in fatigue severity than the G/G genotype (p=0.02). IL1B-511 (rs16944) genotype did not significantly predict changes in fatigue (p values>0.46). Patients with higher numbers of variants displayed greater increases in fatigue duration and interference (p values≤0.02) than patients with lower numbers of variants. Prostate cancer patients treated with ADT who carry variant alleles of the IL6 and TNFA genes are susceptible to heightened fatigue. These preliminary data lend support for the role of genetic variation in the development of cancer-related fatigue secondary to ADT. Findings are relevant to attempts to develop personalized approaches to cancer treatment.
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影响因子：
3.5
作者：
Hann, DM;Denniston, MM;Baker, F
通讯作者：
Baker, F
影响因子：
3.7
作者：
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影响因子：
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作者：
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DOI：
10.1016/s0360-3016(01)01657-1
发表时间：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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