Quantifying ventilation by X-ray velocimetry in healthy adults.
Quantifying ventilation by X-ray velocimetry in healthy adults.
复制标题
DOI：
10.1186/s12931-023-02517-z
复制
发表时间：
2023-08-30
影响因子：
5.8
通讯作者：
中科院分区：
文献类型：
--
作者：
x射线测速（XV）已被用于临床前模型，以评估肺运动和局部通气，尽管没有研究将XV衍生的生理参数与传统方法衍生的测量结果进行比较。评估x - v分析肺透视图像与皮托管流量计通气测量之间的一致性。比较潮汐呼吸和双水平辅助呼吸时的XV和皮托管衍生通气参数。使用Bland-Altman分析评估一致性水平。混合模型用于表征XV和皮托管衍生值之间的关联，并优化XV衍生值以获得更高的通气量。24名健康志愿者在潮汐呼吸时进行评估，11名志愿者在双水平辅助呼吸下增加分分钟通气后进行重新评估。两种方法在呼吸频率（平均Δ： 0.58； 95%一致限：-1.55,2.71）或占空比（平均Δ： 0.02； 95%一致限：0.01,0.03）方面无临床显著差异。使用XV测量的潮汐体积和流速低于使用皮托管流量计测量的潮汐体积和流速，特别是在双水平辅助呼吸的较高体积范围内。在此条件下，对xv导出的潮汐体积和流速值进行了基于混合模型的调整，以获得与皮托管导出值更接近的结果。x线摄影获得的XV通风测量显示与通风参数高度相关。如果XV的准确性也被证实用于评估通气的区域分布，它将提供超出常规肺功能测试或静态放射学评估范围的信息。在线版本包含补充材料，可在10.1186/s12931-023-02517-z获得。
X-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conventional means. To assess agreement between XV-analysis of fluoroscopic lung images and pitot tube flowmeter measures of ventilation. XV- and pitot tube-derived ventilatory parameters were compared during tidal breathing and with bilevel-assisted breathing. Levels of agreement were assessed using the Bland-Altman analysis. Mixed models were used to characterize the association between XV- and pitot tube-derived values and optimize XV-derived values for higher ventilatory volumes. Twenty-four healthy volunteers were assessed during tidal breathing and 11 were reassessed with increased minute ventilation with bilevel-assisted breathing. No clinically significant differences were observed between the two methods for respiratory rate (average Δ: 0.58; 95% limits of agreement: -1.55, 2.71) or duty cycle (average Δ: 0.02; 95% limits of agreement: 0.01, 0.03). Tidal volumes and flow rates measured using XV were lower than those measured using the pitot tube flowmeter, particularly at the higher volume ranges with bilevel-assisted breathing. Under these conditions, a mixed-model based adjustment was applied to the XV-derived values of tidal volume and flow rate to obtain closer agreement with the pitot tube-derived values. Radiographically obtained measures of ventilation with XV demonstrate a high degree of correlation with parameters of ventilation. If the accuracy of XV were also confirmed for assessing the regional distribution of ventilation, it would provide information that goes beyond the scope of conventional pulmonary function tests or static radiographic assessments. The online version contains supplementary material available at 10.1186/s12931-023-02517-z.
登录
查看更多内容
影响因子：
3.2
作者：
Kirkness, J. P.;Verma, M.;Schneider, H.
通讯作者：
Schneider, H.
影响因子：
4.6
作者：
Murrie, Rhiannon P.;Werdiger, Freda;Fouras, Andreas
通讯作者：
Fouras, Andreas
影响因子：
4.6
作者：
Werdiger, Freda;Donnelley, Martin;Morgan, Kaye S.
通讯作者：
Morgan, Kaye S.
影响因子：
3.9
作者：
Jung T;Vij N
通讯作者：
Vij N
影响因子：
9.6
作者：
Hanania, Alexander N.;Mainwaring, Walker;Ludwig, Michelle
通讯作者：
Ludwig, Michelle