Clinical features and serum cytokine profiles of elderly-onset adult-onset Still's disease.
Clinical features and serum cytokine profiles of elderly-onset adult-onset Still's disease.
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DOI：
10.1038/s41598-022-25514-6
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发表时间：
2022-12-09
影响因子：
4.6
通讯作者：
Matsumoto, Isao
中科院分区：
文献类型：
--
作者：
Yagishita, Mizuki;Tsuboi, Hiroto;Kuroda, Yuki;Sawabe, Tomonori;Kawashima, Akira;Kawashima, Fumina;Uematsu, Nana;Sato, Ryota;Nishiyama, Taihei;Terasaki, Mayu;Toko, Hirofumi;Honda, Fumika;Ohyama, Ayako;Abe, Saori;Kitada, Ayako;Miki, Haruka;Hagiwara, Shinya;Kondo, Yuya;Sumida, Takayuki;Matsumoto, Isao
最近的研究表明，老年性成人起病斯蒂尔病(AOSD)的临床特征与中青年患者不同，但具体细节尚不清楚，老年AOSD的细胞因子谱尚未见报道。为了阐明老年AOSD的临床特征和细胞因子谱，我们检查了2006年1月至2021年9月期间发生这种疾病的AOSD患者。我们将患者分为中青年起病组(老年组 <； 65岁)和老年组(老年组65岁 ≥ )，从患者特征、临床症状、血清白介素6和白介素18等实验室检查结果、治疗和预后等方面进行比较。共检查48例患者(老年组10例)。老年起病组不典型皮疹的发生率明显高于非典型皮疹，典型皮疹和脾肿大的发生率明显减少，白细胞计数和中性粒细胞比率显著升高，血清IL-6水平显著降低。血清IL-6水平与发病年龄呈显著负相关。两组之间的治疗和复发情况相似，而老年组的感染发生率明显更高。老年AOSD的临床特征和细胞因子谱可能不同于中青年AOSD。
Recent studies have suggested that the clinical features of elderly-onset adult-onset Still’s disease (AOSD) differ from those of young and middle-aged-onset patients, whereas the details remain unclear, and cytokine profiles of elderly-onset AOSD have not been reported. To clarify the clinical features and cytokine profiles of elderly-onset AOSD, we examined patients with AOSD who developed the disease between January 2006 and September 2021. We divided the patients into the young and middle-aged-onset group (aged < 65 years) and the elderly-onset group (aged ≥ 65 years) and compared the groups in terms of patient characteristics, clinical symptoms, laboratory findings including serum interleukin (IL)-6 and IL-18, treatment, and prognosis. A total of 48 patients were examined (10 in the elderly-onset group). In the elderly-onset group, atypical rash was significantly more frequent, typical rash and splenomegaly were significantly less frequent, white blood cell count and neutrophil ratio were significantly higher and serum IL-6 levels were significantly lower. Serum IL-6 showed a significantly negative correlation with age at onset. Treatment and relapse were comparable between the 2 groups, whereas infections were significantly more frequent in the elderly-onset group. The clinical features and cytokine profiles of elderly-onset AOSD might differ from those of young and middle-aged-onset AOSD.
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DOI：
10.1007/s13317-015-0071-9
发表时间：
2015-12
期刊：
Auto- immunity highlights
影响因子：
--
作者：
Michailidou D;Shin J;Forde I;Gopalratnam K;Cohen P;DeGirolamo A
通讯作者：
DeGirolamo A
影响因子：
7.9
作者：
Pinke, Karen Henriette;Calzavara, Bruno;Lara, Vanessa Soares
通讯作者：
Lara, Vanessa Soares
影响因子：
3.7
作者：
Di Cola, I.;Di Muzio, C.;Ruscitti, P.
通讯作者：
Ruscitti, P.
影响因子：
3.9
作者：
Rau, Monika;Schiller, Martin;Blank, Norbert
通讯作者：
Blank, Norbert
影响因子：
8.6
作者：
Inoue, Natsumi;Shimizu, Masaki;Yachie, Akihiro
通讯作者：
Yachie, Akihiro