Characteristics of academic publications, preprints, and registered clinical trials on the COVID-19 pandemic.
Characteristics of academic publications, preprints, and registered clinical trials on the COVID-19 pandemic.
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DOI：
10.1371/journal.pone.0240123
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Castellini G
中科院分区：
文献类型：
--
作者：
Gianola S;Jesus TS;Bargeri S;Castellini G
2019冠状病毒病大流行引发了大量出版物。在这项横断面研究中，我们比较了与covid -19相关的学术文章和预印本的数量和报告特征，以及正在进行的临床试验和系统评价的数量。为此，我们在PubMed数据库中检索了已发表的生命科学期刊的引文和摘要，使用适当的医学主题词（MeSH术语）组合，以及MedRxiv和BioRxiv档案的COVID-19部分，检索时间截止到2020年5月20日（21周）。此外，我们检索了Clinicaltrial.gov、中国临床试验注册中心、欧盟临床试验注册中心和其他15个试验注册中心，以及国际前瞻性系统评价注册中心PROSPERO。提取了每份出版物的特征。回归分析和Z检验用于检测发表趋势及其相对比例。共检索学术出版物3635篇，预印本3805篇。只有8.6% （n = 329）的预印本已经在有索引的期刊上发表。随着时间的推移，学术和预印本出版物的数量显著增加（p<0.001）。案例报告（学术报告6% vs预印本0.9%,p<0.001）和信件（学术报告17.4% vs预印本0.5%,p<0.001）在学术出版物中所占的份额大于预印本出版物。不同的是，随机对照试验（0.22% vs 0.63%; p<0.001）和系统评价（0.08% vs 5%）占预印本的比例更大。在Clinicaltrials.gov、Chinese clinical Trial Registry和EU clinical Trials Register注册的临床研究相对比例分别为57.9%、49.5%和98.9%，其中大部分仍处于“招募”阶段。普洛斯彼罗列出了962项系统评价方案。预印本略高于学术论文，但两者的数量都在增加。缺乏初步研究留下的空白被发表在pubmed索引期刊上的大量即时意见（即给编辑的信）所填补。总而言之，在当前大流行期间，预印本作为出版业对迅速获得经验性（尽管未经同行评审）研究结果的需求的回应而获得了吸引力。
The COVID-19 pandemic has unleashed a deluge of publications. For this cross-sectional study we compared the amount and reporting characteristics of COVID-19-related academic articles and preprints and the number of ongoing clinical trials and systematic reviews. To do this, we searched the PubMed database of citations and abstracts for published life science journals by using appropriate combinations of medical subject headings (MeSH terms), and the COVID-19 section of the MedRxiv and BioRxiv archives up to 20 May 2020 (21 weeks). In addition, we searched Clinicaltrial.gov, Chinese Clinical Trial Registry, EU Clinical Trials Register, and 15 other trial registers, as well as PROSPERO, the international prospective register of systematic reviews. The characteristics of each publication were extracted. Regression analyses and Z tests were used to detect publication trends and their relative proportions. A total of 3635 academic publications and 3805 preprints were retrieved. Only 8.6% (n = 329) of the preprints were already published in indexed journals. The number of academic and preprint publications increased significantly over time (p<0.001). Case reports (6% academic vs 0.9% preprints; p<0.001) and letters (17.4% academic vs 0.5% preprints; p<0.001) accounted for a greater share of academic compared to preprint publications. Differently, randomized controlled trials (0.22% vs 0.63%; p<0.001) and systematic reviews (0.08% vs 5%) made up a greater share of the preprints. The relative proportion of clinical studies registered at Clinicaltrials.gov, Chinese Clinical Trial Registry, and EU Clinical Trials Register was 57.9%, 49.5%, and 98.9%, respectively, most of which were still “recruiting”. PROSPERO listed 962 systematic review protocols. Preprints were slightly more prevalent than academic articles but both were increasing in number. The void left by the lack of primary studies was filled by an outpour of immediate opinions (i.e., letters to the editor) published in PubMed-indexed journals. Summarizing, preprints have gained traction as a publishing response to the demand for prompt access to empirical, albeit not peer-reviewed, findings during the present pandemic.
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影响因子：
3.7
作者：
Falagas ME;Papastamataki PA;Bliziotis IA
通讯作者：
Bliziotis IA
影响因子：
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作者：
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通讯作者：
Ziebuhr, John
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6.1
作者：
Haghani, Milad;Bliemer, Michiel C. J.;Li, Jie
通讯作者：
Li, Jie