Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth.
Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth.
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使用 stanniocalcin-1 抗血清对哺乳期小鼠进行被动免疫会降低乳腺发育、乳脂含量和产后幼仔的生长。
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
G. F. Wagner
中科院分区：
文献类型：
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作者：
D. Zaidi;K. James;G. F. Wagner
在啮齿类动物怀孕和哺乳期间，卵巢产生的斯钙素-1 (STC-1) 显着上调并释放到循环中。乳腺是这种全身输送激素的目标之一。本研究的目的是通过被动免疫降低哺乳期小鼠血清STC-1水平，以监测其对乳腺功能和产后幼仔生长的影响。被动免疫显着降低了循环激素水平，并且幼崽的生长受到显着影响（30%），即使对照和实验窝摄入了等量的牛奶。对乳腺进行分析时发现，接受抗体治疗的母亲的乳腺面积显着减少。对牛奶成分的分析显示，乳糖、蛋白质或电解质水平没有变化，但甘油三酯水平降低了约 40%。后者是由于乳腺脂蛋白脂肪酶活性显着降低并导致血清中甘油三酯显着积聚。接受抗体处理的母亲的幼仔体内脂肪含量也显着降低，而幼仔粪便脂肪含量则增加。对于母亲来说，被动免疫也造成了显着的行为影响，特别是增加了运动和后腿的饲养活动。总的来说，结果表明系统衍生的 STC-1 对乳腺发育和血清甘油三酯转移到乳汁中具有重要影响。运动效应表明 STC-1 在母亲行为中也发挥着作用。
During pregnancy and lactation in rodents, stanniocalcin-1 (STC-1) production by the ovaries is upregulated markedly and released into the circulation. The mammary glands are one target of this systemically delivered hormone. The purpose of this study was to lower serum levels of STC-1 in lactating mice through passive immunization so as to monitor the effects on mammary gland function and postnatal pup growth. Passive immunization significantly reduced circulating hormone levels, and pup growth was significantly compromised (30%), even though control and experimental litters had ingested equal amounts of milk. When mammary glands were analyzed, the alveolar area was significantly reduced in antibody-treated mothers. An analysis of milk composition revealed no changes in lactose, protein, or electrolyte levels but an approximately 40% reduction in triglyceride levels. The latter was due to a significant reduction in mammary gland lipoprotein lipase activity and led to a significant buildup of triglycerides in the serum. Body fat content was also significantly reduced in pups from antibody-treated mothers, whereas pup fecal fat content was increased. In mothers, passive immunization also caused significant behavioral effects, in particular, increased locomotor and hindleg rearing activities. Collectively, the results suggest that systemically derived STC-1 has important effects on mammary gland development and the transfer of serum-based triglycerides into milk. Locomotor effects suggest that STC-1 also has a role in maternal behavior.
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
通讯作者：
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影响因子：
4.1
作者：
JENSEN, DR;GAVIGAN, S;NEVILLE, MC
通讯作者：
NEVILLE, MC
DOI：
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发表时间：
1988-12
期刊：
The American journal of pathology
影响因子：
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作者：
Janice F. Sissom;Marsha L. Eigenbrodt;andJOHN C. Porter
通讯作者：
Janice F. Sissom;Marsha L. Eigenbrodt;andJOHN C. Porter
小鼠乳腺脂蛋白脂肪酶的分布和来源。
影响因子：
6.5
作者：
Jensen,DR;Bessesen,DH;Etienne,J;Eckel,RH;Neville,MC
通讯作者：
Neville,MC
神经肽Y的免疫中和对正常小鼠和带有牛生长激素基因的转基因小鼠促性腺激素和催乳素分泌的影响。
影响因子：
4.8
作者：
Ghosh,PK;Debeljuk,L;Wagner,TE;Bartke,A
通讯作者：
Bartke,A