Endocannabinoid system in neurodegenerative disorders.
Endocannabinoid system in neurodegenerative disorders.
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DOI：
10.1111/jnc.14098
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发表时间：
2017-09
影响因子：
4.7
通讯作者：
Subbanna S
中科院分区：
文献类型：
--
作者：
Basavarajappa BS;Shivakumar M;Joshi V;Subbanna S
大多数神经退行性疾病（NDD）的特征在于认知障碍和其他神经缺陷。这些NDD进展的确切原因和途径尚未明确。已经提出了几种机制来促进国家荒漠化发展。这些机制可以同时或相继进行，并且它们在不同大脑区域的不同发育阶段的细胞类型之间存在差异。内源性大麻素系统，其中涉及大麻素受体1型（CB1R）和2型（CB2R），内源性大麻素和分解代谢这些化合物的酶，已被证明有助于在几个动物模型和人类研究的NDD的发展。本文综述了内源性大麻素系统在NDD中的作用，并匡威了靶向内源性大麻素系统治疗NDD的疗效。在此问题描述中：阿尔茨海默病（AD）、亨廷顿病（HD）和帕金森病（PD）的特征在于认知损害和其他神经缺陷。虽然这些疾病进展的潜在机制尚未明确，但在几种动物模型和人体研究中，内源性大麻素系统已被证明有助于AD，HD和PD中发现的神经功能缺损。综述提供了最新进展，并讨论了靶向内源性大麻素系统的治疗潜力，以挽救AD，HD和PD的一些神经系统缺陷。
Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well defined. Several mechanisms have been proposed to contribute to the development of NDDs. These mechanisms may proceed concurrently or successively, and they differ among cell types at different developmental stages in distinct brain regions. The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enzymes that catabolize these compounds, has been shown to contribute to the development of NDDs in several animal models and human studies. In this review, we discuss the functions of the endocannabinoid (EC) system in NDDs and converse the therapeutic efficacy of targeting the endocannabinoid system to rescue NDDs. In this issue description: The Alzheimer (AD), Huntington (HD) and Parkinson (PD) diseases are characterized by cognitive impairment and other neurological defects. Although the mechanisms underlying the progression of these diseases are not well defined, the endocannabinoid system has been shown to contribute to the neurologic deficits found in AD, HD and PD in several animal models and human studies. The review provides a recent progress and discusses the therapeutic potential of targeting the endocannabinoid system to rescue some of the neurological defects of AD, HD, and PD.
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影响因子：
5.3
作者：
Arrasate, Montserrat;Finkbeiner, Steven
通讯作者：
Finkbeiner, Steven
DOI：
10.1006/bbrc.1999.0254
发表时间：
1999-03-16
影响因子：
3.1
作者：
Bisogno, T;Berrendero, F;Di Marzo, V
通讯作者：
Di Marzo, V
影响因子：
6.1
作者：
Battista, Natalia;Bari, Monica;Maccarrone, Mauro
通讯作者：
Maccarrone, Mauro
影响因子：
5.7
作者：
Biegon, A;Kerman, IA
通讯作者：
Kerman, IA
影响因子：
5.3
作者：
Austin, Susan A.;Floden, Angela M.;Combs, Colin K.
通讯作者：
Combs, Colin K.