Hypoglycaemic activity of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione in streptozotocin-induced diabetic mice through ameliorating metabolic function and regulating peroxisome proliferator-activated receptor γ.
Hypoglycaemic activity of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione in streptozotocin-induced diabetic mice through ameliorating metabolic function and regulating peroxisome proliferator-activated receptor γ.
复制标题
DOI：
10.5114/aoms.2016.63285
复制
发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Huang R
中科院分区：
文献类型：
--
作者：
Kintoko K;Xu X;Lin X;Jiao Y;Wen Q;Chen Z;Wei J;Liang T;Huang R
Diabetes mellitus is characterized by hyperglycaemia causing changes in plasma lipoproteins, which leads to insulin resistance, secretion defects or both. The present study aimed to evaluate the ability of 2-dodecyl-6-methoxy-cyclohexa-2,5-diene-1,4-dione (DMDD) isolated from Averrhoa carambola L. roots to lower hyperglycaemia and to investigate its potential mechanism in diabetic mice. DMDD was isolated using a column chromatographic technique. Experimental mice were fed with a high-fat diet for a month and were intravenously injected with streptozotocin (80 mg/kg, single dose). Diabetic mice were orally administered DMDD (12.5, 25, 50 mg/kg) and 50 mg/kg pioglitazone for 15 days. Fasting blood glucose (FBG), fasting blood insulin (FINS), pancreatic insulin content, interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), as well as serum total cholesterol (TC), triglyceride (TG) and free fatty acid (FFA) were determined. Adipose tissue was assessed by histological examination, immunohistochemistry, western blot and reverse transcription-polymerase chain reaction methods. DMDD significantly increased the insulin level (all p < 0.05). In contrast, FBG, IL-6, TNF-α, TC, TG and FFA were significantly decreased (all p < 0.05). However, DMDD induced the activation of adipocyte peroxisome proliferator-activated receptor γ (PPAR-γ), confirmed by increased protein and mRNA expression of PPAR-γ. DMDD possessed hypoglycaemic activity due to its potential mechanism involving PPARγ-mediated adipocyte endocrine regulation.
登录
查看更多内容
影响因子：
2.4
作者：
Liu A;Sonmez A;Yee G;Bazuine M;Arroyo M;Sherman A;McLaughlin T;Reaven G;Cushman S;Tsao P
通讯作者：
Tsao P
DOI：
10.1073/pnas.96.20.11513
发表时间：
1999-09-28
影响因子：
11.1
作者：
Higa, M;Zhou, YT;Unger, RH
通讯作者：
Unger, RH
影响因子：
7.9
作者：
Naik, Suresh R.;Niture, Netaji T.;Shah, Priyank D.
通讯作者：
Shah, Priyank D.
影响因子：
3.4
作者：
Bhandari, U.;Jain, N.;Pillai, K. K.
通讯作者：
Pillai, K. K.
DOI：
10.1002/food.200300354
发表时间：
2004-02-01
期刊：
NAHRUNG-FOOD
影响因子：
--
作者：
Chau, CF;Chen, CH;Lee, MH
通讯作者：
Lee, MH