Epidemiology and clinical aspects on hepatitis C.
Epidemiology and clinical aspects on hepatitis C.
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丙型肝炎的流行病学和临床方面。
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
K. Kiyosawa
中科院分区：
文献类型：
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作者：
M. Higuchi;E. Tanaka;K. Kiyosawa
丙型肝炎病毒（HCV）感染估计1.7亿人全世界，200万人在日本。HCV是慢性肝病，特别是肝癌的主要原因，并且HCV相关肝细胞癌（HCC）患者的数量在全世界以及日本都在增加。大多数急性丙型肝炎患者发展为慢性肝炎。丙型慢性肝病患者中丙型肝炎病毒的自发消失并不常见，并且在大多数情况下，它往往会发展为进一步晚期和更严重的肝脏疾病，最终在30年内发展为肝细胞癌。由于HCV感染引起的慢性肝病通常与肝外表现相关，例如冷球蛋白血症。单用干扰素抗病毒治疗HCV感染24周，持续病毒学应答（SVR）率较低（低于10%），尤其是在HCV基因型1b和HCV RNA浓度高的患者中。然而，干扰素和利巴韦林的联合治疗提高了SVR率。最近，聚乙二醇干扰素用于治疗慢性丙型肝炎导致高SVR率。这些抗病毒治疗方式将减少HCC的发生。到目前为止，尽管做出了许多努力，但仍然没有HCV疫苗。
Hepatitis C virus (HCV) infects an estimated 170 million persons worldwide, and 2 million persons in Japan. HCV is a major cause of chronic liver diseases, especially hepatocarcinogenesis, and the number of patients with HCV-related hepatocellular carcinoma (HCC) is increasing worldwide as well as in Japan. Most patients with acute hepatitis C develop chronic hepatitis. Spontaneous disappearance of HCV in patients with type C chronic liver disease is uncommon, and it tends to progress to further advanced and more severe liver disease, ultimately to HCC over a period of 30 years in most cases. Chronic liver disease due to HCV infection is commonly associated with extrahepatic manifestation, for example cryoglobulinemia. Antiviral treatment for HCV infection with interferon alone during 24 weeks was associated with a low rate (less than 10%) of sustained virologic response (SVR), especially in patients infected with HCV genotype 1b and high HCV RNA concentration. However, combination therapy of interferon and ribavirin raises the SVR rate. More recently, pegylated interferon used for treatment of chronic hepatitis C resulted in a high SVR rate. These modalities of antiviral treatment will reduce HCC occurrence. So far, there is no HCV vaccine in spite of many efforts.
影响因子：
158.5
作者：
McHutchison, JG;Gordon, SC;Albrecht, JK
通讯作者：
Albrecht, JK
患有肝细胞癌的日裔美国人中的乙型和丙型肝炎病毒血清学。
DOI：
10.1093/infdis/173.6.1474
发表时间：
1996
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Nomura,A;Stemmermann,GN;Chyou,PH;Tabor,E
通讯作者：
Tabor,E