Papillary urothelial hyperplasia. A precursor to papillary neoplasms.
Papillary urothelial hyperplasia. A precursor to papillary neoplasms.
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尿路上皮乳头增生。
DOI：
10.1097/00000478-199612000-00007
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
J. Epstein
中科院分区：
文献类型：
--
作者：
David C. Taylor;B. Bhagavan;Moira P. Larsen;Joseph A. Cox;J. Epstein
乳头状尿路上皮肿瘤的前驱病变尚未得到很好的描述。我们回顾了约翰霍普金斯医院和三家地区医院从1992年到现在的外科病理档案。16例乳头状增生症，定义为波状的尿路上皮排列成薄的粘膜乳头状皱折(男11例，女5例，年龄40-89岁)。相对于乳头状增生症的诊断，9例患者有乳头状尿路上皮肿瘤病史；其中1例患者随后还出现乳头状尿路上皮肿瘤，其中2例合并乳头状尿路上皮肿瘤和乳头状增生。在这9例中的1例中，乳头状增生出现在先前乳头状尿路上皮肿瘤的瘢痕中。在两个病例中，患者同时有乳头状尿路上皮肿瘤，但没有既往病史。在这11例中，3例随着时间的推移有多次切除，显示乳头状增生。在病例12中，患者有中度尿路上皮异型性病史。其余4名患者无乳头状尿路上皮肿瘤或尿路上皮异型性病史。我们将乳头状增生描述为一种定义明确的实体，通常无症状，通常可在乳头状尿路上皮肿瘤的常规后续膀胱镜检查中发现。乳头状增生似乎是低度乳头状尿路上皮肿瘤的前驱病变。
Precursor lesions of papillary urothelial neoplasms have not been well characterized. We reviewed the surgical pathology files of the Johns Hopkins Hospital and three regional hospitals from 1992 to present. Sixteen cases of papillary hyperplasia, defined as undulating urothelium arranged into thin mucosal papillary folds, were identified (in 11 men and five women: age range, 40-89 years). Relative to the diagnosis of papillary hyperplasia, nine patients had a history of papillary urothelial neoplasms; in one of these cases, the patient also had subsequent papillary urothelial neoplasms, and two of these patients had concurrent papillary urothelial neoplasms with papillary hyperplasia. In one of these nine cases, papillary hyperplasia arose in the scar of a prior papillary urothelial neoplasm. In two cases, the patients had concurrent, yet no prior history, of papillary urothelial neoplasms. Of these 11 cases, three had multiple resections showing papillary hyperplasia over time. In case 12, the patient had a history of moderate urothelial atypia. The remaining four patients had no history of papillary urothelial neoplasms or urothelial atypia. We describe papillary hyperplasia as a well-defined entity that is usually asymptomatic and generally found on routine follow-up cystoscopy for papillary urothelial neoplasms. Papillary hyperplasia appears to be a precursor lesion of low-grade papillary urothelial neoplasms.
影响因子：
3.8
作者：
Samuel Monroe Cohen
通讯作者：
Samuel Monroe Cohen