Cognitive mechanisms of memory for order in rhesus monkeys (Macaca mulatta).
Cognitive mechanisms of memory for order in rhesus monkeys (Macaca mulatta).
复制标题
恒河猴（Macaca mulatta）秩序记忆的认知机制。
DOI：
10.1002/hipo.22082
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发表时间：
2013
期刊：
影响因子：
3.5
通讯作者：
Hampton,RobertR
中科院分区：
文献类型：
--
作者：
Templer,VictoriaL;Hampton,RobertR
情景记忆的一个重要方面是记住事件发生顺序的能力。大鼠对序列的记忆已经显示依赖于海马和内侧前额叶皮质（DeVito和Eichenbaum（2011）J Neuro 31：3169 - 3175; Fortin等人（2002）Nat Neuro 5：458 - 462）。具有海马损伤的大鼠在选择在五种气味的序列中较早出现的气味方面受损，但在识别先前采样的气味方面没有受损（Fortin等人，2002; Kesner等人（2002）Behav Neuro 116：286 - 290）。这些结果表明，顺序不是由相对熟悉度或记忆强度来表示的。然而，顺序记忆的认知机制尚未确定。我们向猴子展示了从6,000张图片中随机抽取的五张图片。在测试中，两个图像被呈现，猴子们选择了在研究列表中出现较早的图像。猴子学会了区分图像的顺序，即使是那些在研究列表中连续的图像。在随后的实验中，我们发现顺序辨别不受列表位置或相对记忆强度的控制。相反，猴子使用时间顺序，这是一种似乎编码相对于其他事件发生顺序的机制，而不是绝对时间。我们发现，干预图像的数量，而不是时间本身的推移，最强烈地决定了发生顺序的可辨别性。更好地说明非人类灵长类动物用来记住事件顺序的认知机制，增强了这种情景记忆的动物模型，并可能进一步告知我们对海马体功能的理解。© 2012 Wiley Periodicals，Inc.
One important aspect of episodic memory is the ability to remember the order in which events occurred. Memory for sequences in rats and has been shown to rely on the hippocampus and medial prefrontal cortex (DeVito and Eichenbaum (2011) J Neuro 31:3169‐3175; Fortin et al. (2002) Nat Neuro 5:458‐462). Rats with hippocampal lesions were impaired in selecting the odor that had appeared earlier in a sequence of five odors but were not impaired in recognition of previously sampled odors (Fortin et al., 2002; Kesner et al. (2002) Behav Neuro 116:286‐290). These results suggest that order is not represented by relative familiarity or memory strength. However, the cognitive mechanisms underlying memory for order have not been determined. We presented monkeys with lists of five images drawn randomly from a pool of 6,000 images. At test, two images were presented and monkeys were rewarded for selecting the image that had appeared earlier in the studied list. Monkeys learned to discriminate the order of the images, even those that were consecutive in the studied list. In subsequent experiments, we found that discrimination of order was not controlled by list position or relative memory strength. Instead, monkeys used temporal order, a mechanism that appears to encode order of occurrence relative to other events, rather than in absolute time. We found that number of intervening images, rather than passage of time per se, most strongly determined the discriminability of order of occurrence. Better specifying the cognitive mechanisms nonhuman primates use to remember the order of events enhances this animal model of episodic memory, and may further inform our understanding of the functions of the hippocampus. © 2012 Wiley Periodicals, Inc.
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DOI：
10.1016/s0769-2625(87)80081-8
发表时间：
1987
期刊：
Annales de l'Institut Pasteur. Immunology
影响因子：
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作者：
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作者：
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DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
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作者：
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通讯作者：
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