Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review.
Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review.
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作者：
Ali S;Garcia JM
到2050年，65岁以上的人将占美国人口的20%。肌肉质量和力量的丧失在这个年龄段很常见，它与更多的依赖性、虚弱和死亡率有关。骨质疏松症被定义为与衰老相关的肌肉质量和功能的丧失，恶病质被定义为由于潜在疾病而导致的体重减轻，这些都是与老龄化人口特别相关的肌肉损耗疾病，但它们在很大程度上没有被发现。在这篇综述中，我们强调了石棺减少和恶病质肌肉丢失的常见病理生理学机制，每种情况下的独特因素以及临床诊断和鉴别诊断的方法。讨论了包括运动、营养治疗、雄激素、生长激素及其实际局限性在内的治疗选择。我们还阐明了正在开发的作为浪费疾病的潜在治疗选择的新药物。
By the year 2050, individuals over the age of 65 will comprise 20% of the US population. Loss of muscle mass and strength is common in this age group and it is associated with increased dependence, frailty and mortality. Sarcopenia defined as the loss of muscle mass and function associated with aging, and cachexia defined as weight loss due to an underlying illness, are muscle wasting disorders of particular relevance in the aging population but they go largely unrecognized. In this review we highlight the common pathophysiological mechanisms underlying muscle loss in sarcopenia and cachexia, the factors unique to each condition and means to diagnose and differentiate them clinically. Therapeutic options including exercise, nutritional therapy, androgens, growth hormone and their practical limitations are discussed. We also shed light on newer agents being developed as potential therapeutic options for wasting diseases.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
3.1
作者：
Garcia, Jose M.;Friend, John;Allen, Suzan
通讯作者：
Allen, Suzan
影响因子：
5.8
作者：
Bhasin, Shalender;Cunningham, Glenn R.;Montori, Victor M.
通讯作者：
Montori, Victor M.
影响因子：
3.3
作者：
Drummond, Micah J.;Miyazaki, Mitsunori;Rasmussen, Blake B.
通讯作者：
Rasmussen, Blake B.
影响因子：
45.3
作者：
Jatoi, A;Windschitl, HE;Christensen, B
通讯作者：
Christensen, B