Serum ferritin: Past, present and future.

Serum ferritin: Past, present and future.
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DOI:
10.1016/j.bbagen.2010.03.011
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发表时间:
2010-08
期刊:
Biochimica et biophysica acta
影响因子:
--
通讯作者:
Torti SV
Torti SV
中科院分区:
其他
文献类型:
--
作者:
Wang W;Knovich MA;Coffman LG;Torti FM;Torti SV

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血清铁蛋白在20世纪30年代的S被发现,70年代的S发展为临床试验。许多疾病都与铁负荷或铁缺乏有关。血清铁蛋白被广泛用于诊断和监测这些疾病。在本章中,我们讨论了血清铁蛋白在生理和病理过程中的作用及其作为临床工具的应用。尽管血清铁蛋白的许多基本生物学方面仍然令人惊讶地不清楚,但越来越多的作用被归因于细胞外铁蛋白,包括最近被描述的在铁输送、血管生成、炎症、免疫、信号和癌症中的作用。血清铁蛋白仍然是一种临床有用的工具。对这种蛋白质生物学的进一步研究可能会提供新的生物学见解。
Serum ferritin was discovered in the 1930’s, and was developed as a clinical test in the 1970’s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.
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