Serum ferritin: Past, present and future.
Serum ferritin: Past, present and future.
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DOI:
10.1016/j.bbagen.2010.03.011
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发表时间:
2010-08
期刊:
影响因子:
--
通讯作者:
Torti SV
中科院分区:
文献类型:
--
作者:
Wang W;Knovich MA;Coffman LG;Torti FM;Torti SV
Serum ferritin was discovered in the 1930’s, and was developed as a clinical test in the 1970’s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases. In this chapter, we discuss the role of serum ferritin in physiological and pathological processes and its use as a clinical tool. Although many aspects of the fundamental biology of serum ferritin remain surprisingly unclear, a growing number of roles have been attributed to extracellular ferritin, including newly described roles in iron delivery, angiogenesis, inflammation, immunity, signaling and cancer. Serum ferritin remains a clinically useful tool. Further studies on the biology of this protein may provide new biological insights.
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