Glutathione S‐transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma
Glutathione S‐transferase T1 and M1 genotypes in normal mucosa, transitional mucosa and colorectal adenocarcinoma
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正常粘膜、移行粘膜和结直肠腺癌中谷胱甘肽S-转移酶T1和M1基因型
DOI：
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发表时间：
1999
影响因子：
6.4
通讯作者：
Xiao Feng Sun
中科院分区：
文献类型：
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作者：
Hong Zhang;A. Ahmadi;G. Arbman;J. Zdolsek;J. Carstensen;B. Nordenskjöld;Peter Söderkvistand;Xiao Feng Sun
Gene codings for glutathione S‐transferase T1 (GSTT1) and M1 (GSTM1) are polymorphic in humans with null genotypes present in approximately 20 and 50%, respectively. A significant excess of homozygous null GSTT1 and GSTM1 genotypes has been demonstrated among individuals with certain types of cancers. This finding suggests that GSTT1 and GSTM1 may play a role in tumour susceptibility. However, reports concerning colorectal cancer susceptibility are controversial. In the present study, we used a multiplex polymerase chain reaction (PCR) approach to identify and analyze simultaneously the genotypes of both the genes in 99 patients with colorectal cancer and 109 healthy controls. Compared with the control group, a significant excess of homozygous null genotypes for GSTT1 was found in normal mucosa among the cancer patients, but not for GSTM1. Both genes were more frequently deleted in tumours than in corresponding normal mucosa. Furthermore, GSTT1 null genotype in tumour tissue, was significantly related to old age and to poor differentiation of tumours. GSTM1 null genotype in tumour was more frequent in the rectal tumours compared with tumours of left colon and right colon. Our results suggest that individuals with GSTT1 null genotype may be genetically predisposed for an increased risk of developing colorectal cancer. Allele loss in tumour tissue, which reflects genetic instability, may be considered as a marker for evaluating clinico‐pathological characteristics of the cancer patients. Int. J. Cancer (Pred. Oncol.) 84:135–138, 1999. © 1999 Wiley‐Liss, Inc.
人肝谷胱甘肽 S-转移酶基因超家族：Hb 亚基 cDNA 的表达和染色体作图。
影响因子：
14.9
作者：
DeJong,JL;Chang,CM;Whang-Peng,J;Knutsen,T;Tu,CP
通讯作者：
Tu,CP