Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor.
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DOI：
10.1053/j.gastro.2017.08.045
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发表时间：
2017-12
期刊：
影响因子：
29.4
通讯作者：
Ogino S
中科院分区：
文献类型：
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作者：
Liu L;Nishihara R;Qian ZR;Tabung FK;Nevo D;Zhang X;Song M;Cao Y;Mima K;Masugi Y;Shi Y;da Silva A;Twombly T;Gu M;Li W;Hamada T;Kosumi K;Inamura K;Nowak JA;Drew DA;Lochhead P;Nosho K;Wu K;Wang M;Garrett WS;Chan AT;Fuchs CS;Giovannucci EL;Ogino S
饮食模式影响全身和局部肠道炎症，这与结直肠癌发生有关。慢性炎症可以干扰适应性免疫反应。我们研究了促进肠道炎症的饮食与结直肠癌风险的关联是否对淋巴细胞反应较低的肿瘤比对淋巴细胞反应较高的肿瘤更强。我们从2项前瞻性队列研究的分子病理流行病学数据库中收集数据：护士健康研究（自1976年以来）和健康专业随访研究（自1986年以来）。我们使用重复方法随时间变化的考克斯比例原因特异性风险回归来评估经验性饮食炎症模式（EDIP）评分（来自食物频率问卷数据）与结直肠癌亚型的相关性。有助于高EDIP分数的食物包括红色和加工肉类，精制谷物，碳酸饮料和一些蔬菜;有助于低EDIP分数的食物包括啤酒，葡萄酒，咖啡，茶，黄色和多叶蔬菜和果汁。对结直肠组织样本进行淋巴细胞反应模式（克罗恩样淋巴反应、瘤周淋巴细胞反应、瘤内腺周反应和肿瘤浸润淋巴细胞）的组织学分析。在对124，433名参与者进行随访期间，我们记录了1311例具有可用组织数据的结肠癌和直肠癌病例。EDIP与结直肠癌风险之间的相关性是显著的（P趋势= .02），并且随着瘤周淋巴细胞反应的程度而变化（P异质性< .001）。较高的EDIP评分与无或低瘤周淋巴细胞反应的结直肠癌风险增加相关（最高与最低EDIP评分五分位风险比= 2.60; 95%CI，1.60-4.23; P趋势< .001），但与中等或高瘤周淋巴细胞反应的肿瘤风险无关（P趋势> .80）。在一项前瞻性队列研究中，我们将炎症性饮食与结直肠癌亚型的高风险相关联，该亚型几乎不含或不含瘤周淋巴细胞反应。这些发现表明，饮食相关的炎症可能通过抑制适应性抗肿瘤免疫反应而促进结直肠癌的发展。
Dietary patterns affect systemic and local intestinal inflammation, which have been linked to colorectal carcinogenesis. Chronic inflammation can interfere with the adaptive immune response. We investigated whether the association of a diet that promotes intestinal inflammation with risk of colorectal carcinoma was stronger for tumors with lower lymphocytic reactions than tumors with higher lymphocytic reactions. We collected data from the molecular pathological epidemiology databases of 2 prospective cohort studies: the Nurses’ Health Study (since 1976) and the Health Professional Follow-up Study (since 1986). We used duplication-method time-varying Cox proportional cause-specific hazards regression to assess the association of empirical dietary inflammatory pattern (EDIP) score (derived from food frequency questionnaire data) with colorectal carcinoma subtype. Foods that contribute to high EDIP scores include red and processed meats, refined grains, carbonated beverages, and some vegetables; foods that contribute to low EDIP scores include beer, wine, coffee, tea, yellow and leafy vegetables, and fruit juice. Colorectal tissue samples were analyzed histologically for patterns of lymphocytic reactions (Crohn’s-like lymphoid reaction, peritumoral lymphocytic reaction, intratumoral periglandular reaction, and tumor-infiltrating lymphocytes). During follow up of 124,433 participants, we documented 1311 incident colon and rectal cancer cases with available tissue data. The association between the EDIP and colorectal cancer risk was significant (Ptrend = .02), and varied with degree of peritumoral lymphocytic reaction (Pheterogeneity < .001). Higher EDIP scores were associated with increased risk of colorectal cancer with an absent or low peritumoral lymphocytic reaction (highest vs lowest EDIP score quintile hazard ratio = 2.60; 95% CI, 1.60–4.23; Ptrend < .001) but not risk of tumors with intermediate or high peritumoral lymphocytic reaction (Ptrend > .80). In a prospective cohort study, we associated inflammatory diets with a higher risk of colorectal cancer subtype that contains little or no peritumoral lymphocytic reaction. These findings suggest that diet-related inflammation might contribute to development of colorectal cancer, by suppressing the adaptive anti-tumor immune response.
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DOI：
10.1056/nejmoa1301969
发表时间：
2013-09-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Nishihara R;Wu K;Lochhead P;Morikawa T;Liao X;Qian ZR;Inamura K;Kim SA;Kuchiba A;Yamauchi M;Imamura Y;Willett WC;Rosner BA;Fuchs CS;Giovannucci E;Ogino S;Chan AT
通讯作者：
Chan AT
影响因子：
29.4
作者：
Cao Y;Nishihara R;Qian ZR;Song M;Mima K;Inamura K;Nowak JA;Drew DA;Lochhead P;Nosho K;Morikawa T;Zhang X;Wu K;Wang M;Garrett WS;Giovannucci EL;Fuchs CS;Chan AT;Ogino S
通讯作者：
Ogino S
影响因子：
8
作者：
Kaler, P.;Augenlicht, L.;Klampfer, L.
通讯作者：
Klampfer, L.
影响因子：
105.7
作者：
Mansournia, Mohammad Ali;Altman, Douglas G.
通讯作者：
Altman, Douglas G.
DOI：
10.1158/1940-6207.capr-13-0036
发表时间：
2013-08
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Marzbani E;Inatsuka C;Lu H;Disis ML
通讯作者：
Disis ML