Gene-environment interactions in geriatric depression.
Gene-environment interactions in geriatric depression.
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DOI：
10.1016/j.psc.2011.02.003
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发表时间：
2011-06
影响因子：
1.7
通讯作者：
Lotrich, Francis E.
中科院分区：
文献类型：
--
作者：
Lotrich, Francis E.
患重度抑郁症（MDD）的风险可能受到一系列相互作用的基因和环境的影响。许多老年人暴露于各种潜在的重度抑郁症诱发因素。医学合并症、高炎症状态、照顾者压力和脑血管改变常在发作发生的近端被观察到。此外，一些成年人有暴露于环境压力源的历史，如早期生活创伤，这可能导致终身易患重度抑郁症。尽管有这些暴露，许多人并没有发展成重度抑郁症；基因影响被假设为影响脆弱性和恢复力的因素之一。在过去的七年里，几项研究已经检查了各种基因对这种基因与环境（G×E）相互作用的影响。大多数研究研究了5 -羟色胺转运基因启动子区域的长度多态性，但也有一些研究研究了脑源性神经营养因子、编码下丘脑-垂体-肾上腺轴关键角色的各种基因，以及涉及单胺能、神经内分泌和炎症系统的其他基因。在这些研究的设计上，以及在环境、重度抑郁症和基因分型的测量上，都有明显的差异。由于这种异质性，解释研究中有时不一致的发现变得复杂。然而，一些初步趋势已经出现。概述了这些研究的方法和结果，指出了一致的趋势以及混淆之处。迄今为止取得的进展有望为下一代的研究提供信息。
Risk for the development of major depressive disorder (MDD) is likely influenced by an interacting set of genes and environments. Many elderly are exposed to a variety of potential MDD precipitants. Medical co-morbidities, high inflammatory states, care-giver stress, and cerebrovascular changes are often observed proximal to the development of an episode. Additionally, some adults have histories of exposure to environmental stressors such as early life traumas that may result in a life-long predisposition to MDD. Despite these exposures, many people do not develop MDD; and genetic influences are hypothesized to be one influence on vulnerability and resilience. Over the last seven years, several studies have examined a variety of genes for this gene × environment (G×E) interaction. Most have examined a length polymorphism in the promoter region for the serotonin transporter gene, but some have examined brain derived neurotrophic factor, various genes encoding for key players in the hypothalamic-pituitary-adrenal axis, as well as other genes involved in the monoaminergic, neuroendocrine, and inflammatory systems. There is marked variation in the design of these studies, as well as in the measures of environment, MDD, and genotyping. Interpreting the sometimes inconsistent findings among studies is complicated by this heterogeneity. However, some tentative trends have emerged. An overview is provided of both the methodologies and results of these studies, noting consistent trends as well as confounds. The progress made to date will hopefully inform the next generation of studies.
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作者：
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通讯作者：
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