Anterior claustrum cells are responsive during behavior but not passive sensory stimulation
Anterior claustrum cells are responsive during behavior but not passive sensory stimulation
复制标题
前屏状细胞对行为有反应，但对被动感觉刺激没有反应
DOI：
10.1101/2021.03.23.436687
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Shawn R. Olsen
中科院分区：
文献类型：
--
作者：
D. Ollerenshaw;Julianne Davis;Ethan G. McBride;Andrew M. Shelton;C. Koch;Shawn R. Olsen
屏状核具有独特的位置，可以通过广泛且相互的解剖学投影与几乎所有高阶皮质区域进行通信，但屏状核神经元的体内功能特性尚不清楚。在这里，我们使用小鼠显微内窥镜成像来测量基因标记的 Gnb4+ 屏状核神经元群体的活动。我们发现，当在被动但清醒的条件下传递时，前屏状体中只有一小部分细胞对视觉或听觉刺激有反应。相比之下，在视觉行为任务期间，前屏状核中的大多数细胞受到强烈调节，独立的和空间混合的细胞群显示出相对于自发水平的活动增加或减少。我们的结果表明，前屏状核中的 Gnb4+ 细胞并不代表被动呈现的感觉刺激；相反，这些细胞在与感觉运动转换相关的行为过程中密切参与。
The claustrum is uniquely positioned to communicate with almost all higher-order cortical areas through widespread and reciprocal anatomical projections, yet the in vivo functional properties of claustrum neurons are not well understood. Here we use microendoscope imaging in mice to measure activity in populations of genetically-labelled Gnb4+ claustrum neurons. We find that only a small fraction of cells in the anterior claustrum are responsive to visual or auditory stimuli when delivered under passive yet wakeful conditions. In contrast, during a visual behavioral task, the majority of cells in the anterior claustrum are strongly modulated, with separate and spatially intermingled cell populations showing either increases or decreases in activity relative to spontaneous levels. Our results suggest that the Gnb4+ cells in the anterior claustrum do not represent passively presented sensory stimuli; rather, these cells are strongly engaged during behavior associated with sensory-motor transformations.
视觉屏状体：猫的地形和感受野特性。
DOI：
10.1126/science.7209525
发表时间：
1981
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sherk,H;LeVay,S
通讯作者：
LeVay,S
影响因子：
2.9
作者：
Smith, Jared B.;Watson, Glenn D. R.;Alloway, Kevin D.
通讯作者：
Alloway, Kevin D.