Signal Transmission through MHC Class II Molecules in a Human B Lymphoid Progenitor Cell Line: Different Signaling Pathways Depending on the Maturational Stages of B Cells
Signal Transmission through MHC Class II Molecules in a Human B Lymphoid Progenitor Cell Line: Different Signaling Pathways Depending on the Maturational Stages of B Cells
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人 B 淋巴细胞祖细胞系中 MHC II 类分子的信号传输：根据 B 细胞成熟阶段的不同信号传导途径
DOI：
10.1111/j.1348-0421.1994.tb02154.x
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发表时间：
1994
影响因子：
2.6
通讯作者：
M. Kimoto
中科院分区：
文献类型：
--
作者：
Keiko Naitoh;Y. Ichigi;K. Miyake;A. Muraguchi;M. Kimoto
The function of MHC class II HLA‐DR molecules expressed on a human B lymphoid progenitor cell line FL8.2.4.4 (abbreviated as FL4.4) was examined. FL4.4 cells expressed HLA‐DR molecules and stimulation of the DR molecules by anti‐DR mAb or by superantigen TSST‐1 induced strong augmentation of homocytic aggregation and protein tyrosine phosphorylation in FL4.4 cells. Induced homocytic aggregation in FL4.4 consists both of LFA‐1/ICAM‐1‐dependent and ‐independent pathways as revealed by mAb blocking experiments. Metabolic inhibitors, NaN3 and cytochalasin B, blocked the induced homocytic aggregation of FL4.4. Early mature Daudi B cell lines also showed a similar type of homocytic aggregation by stimulation with anti‐DR mAb. Daudi cells are more sensitive to protein kinase inhibitors herbimycin A and H7 than FL4.4 cells in their blocking of induced homocytic aggregation, while W7 showed stronger inhibitory effects on FL4.4 cells than on Daudi cells. Western blotting analysis revealed that the stimulation of DR molecules induced protein tyrosine phosphorylation of 100‐kDa, 90‐kDa, 60‐kDa and 55‐kDa proteins in FL4.4 cells, while, in Daudi cells 110‐kDa, 100‐kDa and 80‐kDa proteins were phosphorylated. These results suggest that different signaling pathways through class II molecules are employed depending on the maturational stage of B‐cell differentiation.
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蛋白激酶激活在 MHC II 类配体诱导 B 细胞粘附中的作用。
DOI：
--
发表时间：
1992
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fuleihan,R;Spertini,F;Geha,RS;Chatila,T
通讯作者：
Chatila,T
T 细胞接触依赖性 B 细胞激活的建模。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cambier,JC;Morrison,DC;Chien,MM;Lehmann,KR
通讯作者：
Lehmann,KR
MHC II 类信号传导功能的结构划分。
DOI：
10.1016/0167-5699(93)90184-m
发表时间：
1993
期刊：
Immunology today
影响因子：
--
作者：
Wade,WF;Davoust,J;Salamero,J;Andre,P;Watts,TH;Cambier,JC
通讯作者：
Cambier,JC
CD2 CD19 急性淋巴细胞白血病中的双表型白血病淋巴细胞前体及其在人类胎儿造血组织中假定的正常对应物。
影响因子：
20.3
作者：
Uckun,FM;Muraguchi,A;Ledbetter,JA;Kishimoto,T;O'Brien,RT;Roloff,JS;Gajl-Peczalska,K;Provisor,A;Koller,B
通讯作者：
Koller,B
Ia 样和 HLA-A、B 抗原在人多能造血祖细胞上的表达。
影响因子：
20.3
作者：
Fitchen,JH;LeFèvre,C;Ferrone,S;Cline,MJ
通讯作者：
Cline,MJ