A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.
A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β.
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DOI:
10.1016/j.ccr.2014.04.014
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发表时间:
2014-05-12
期刊:
影响因子:
50.3
通讯作者:
Kang Y
中科院分区:
文献类型:
--
作者:
Li W;Kang Y
TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan et al. discover a novel TGF-β-induced lncRNA, lncRNA-ATB, that stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.
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