The hallmarks of cancer: a long non-coding RNA point of view.
The hallmarks of cancer: a long non-coding RNA point of view.
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DOI：
10.4161/rna.20481
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发表时间：
2012-06
期刊：
影响因子：
4.1
通讯作者：
Diederichs S
中科院分区：
文献类型：
--
作者：
Gutschner T;Diederichs S
随着下一代测序方法的出现和转录组分析的进展，很明显，人类基因组包含的不仅仅是蛋白质编码基因。事实上，高达70%的基因组被转录成RNA，而RNA并不作为蛋白质的模板。在这篇综述中，我们重点介绍了这些长链非编码RNA（lncRNA）在肿瘤生物学领域的新作用。发现长ncRNA在几种人类癌症中失调，并显示组织特异性表达。功能研究揭示了lncRNA如HOTAIR、MALAT 1、ANRIL或lincRNA-p21实现其功能的广泛机制。在这里，我们将受长ncRNA影响的细胞过程与癌症的标志联系起来，从而提供了关于肿瘤生物学的ncRNA观点。这将刺激新的研究方向和治疗选择，将长ncRNA视为新的预后标志物和治疗靶点。
With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this review, we focus on the emerging roles of these long non-coding RNAs (lncRNAs) in the field of tumor biology. Long ncRNAs were found to be deregulated in several human cancers and show tissue-specific expression. Functional studies revealed a broad spectrum of mechanisms applied by lncRNAs such as HOTAIR, MALAT1, ANRIL or lincRNA-p21 to fulfill their functions. Here, we link the cellular processes influenced by long ncRNAs to the hallmarks of cancer and therefore provide an ncRNA point-of-view on tumor biology. This should stimulate new research directions and therapeutic options considering long ncRNAs as novel prognostic markers and therapeutic targets.
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