T-cell-mediated immunological barriers to xenotransplantation.
T-cell-mediated immunological barriers to xenotransplantation.
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T细胞介导的免疫障碍物的异种移植。
DOI：
10.1111/j.1399-3089.2011.00687.x
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发表时间：
2012-01
影响因子：
3.9
通讯作者：
Yamada K
中科院分区：
文献类型：
--
作者：
Scalea J;Hanecamp I;Robson SC;Yamada K
异种移植仍然是临床移植中显着扩大供体器官库的最可行的选择。随着核移植技术的出现，转基因猪的生产已成为可能。这些动物使移植研究人员能够克服实验性猪到非人灵长类动物模型中超急性异种移植排斥的体液机制。然而，其他免疫障碍阻碍了异种移植物的长期接受。这篇综述文章重点关注异种排斥的一个主要特征：异种 T 细胞反应。从小型和大型动物模型（特别是使用胰岛细胞或肾脏的动物模型）获得的证据表明，T 细胞反应在异种排斥中发挥着重要作用，并且单独的免疫抑制可能无法完全抑制这些反应。此外，抗原呈递的直接和间接途径似乎都参与了这些抗供体过程。加深对 (i) CD47 及其在转导异种骨髓中的作用 (ii) CD39 及其在凝血失调中的作用以及 (iii) 胸腺移植的理解，为我们提供了令人鼓舞的结果。目前，评估异种耐受可能性的实验正在进行中。
Xenotransplantion remains the most viable option for significant expansion of the donor organ pool in clinical transplantation. With the advent of nuclear transfer technologies, the production of transgenic swine has become a possibility. These animals have allowed transplant investigators to overcome humoral mechanisms of hyper-acute xenograft rejection in experimental pig-to-non-human primate models. However, other immunologic barriers preclude long-term acceptance of xenografts. This review article focuses on a major feature of xenogeneic rejection: xenogeneic T cell responses. Evidence obtained from both small and large animal models, particularly those using either islet cells or kidneys, have demonstrated that T cell responses play a major role in xenogeneic rejection, and that immunosuppression alone is likely incapable of completely suppressing these responses. Additionally, both the direct and indirect pathway of antigen presentation appear to be involved in these anti donor processes. Enhanced understanding of (i) CD47 and its role in transduced xeno-bone marrow (ii) CD39 and its role in coagulation dysregulation and (iii) thymic transplantation have provided us with encouraging results. Presently, experiments evaluating the possibility of xenogeneic tolerance are underway.
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影响因子：
20.3
作者：
Borsellino, Giovanna;Kleinewietfeld, Markus;Falk, Kirsten
通讯作者：
Falk, Kirsten
影响因子：
6.2
作者：
Benda, B;Sandberg, JO;Korsgren, O
通讯作者：
Korsgren, O
影响因子：
15.9
作者：
Dwyer, KM;Robson, SC;d'Apice, AJF
通讯作者：
d'Apice, AJF
DOI：
10.1073/pnas.0609661104
发表时间：
2007-03-20
影响因子：
11.1
作者：
Ide, Kentaro;Wang, Hui;Ohdan, Hideki
通讯作者：
Ohdan, Hideki
影响因子：
82.9
作者：
Cardona, K;Korbutt, GS;Larsen, CP
通讯作者：
Larsen, CP