Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M.
Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1α, TNFα and oncostatin M.
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DOI：
10.1371/journal.pone.0101937
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Morel F
中科院分区：
文献类型：
--
作者：
Rabeony H;Petit-Paris I;Garnier J;Barrault C;Pedretti N;Guilloteau K;Jegou JF;Guillet G;Huguier V;Lecron JC;Bernard FX;Morel F
角质细胞分化程序导致一个有组织的表皮在维持皮肤的第一道防线中起着关键作用。表皮完整性由角质形成细胞和白细胞之间的紧密通讯调节，特别是在细胞因子控制下。细胞因子网络的失衡导致炎症性疾病，如牛皮癣。我们对皮肤炎症模型的尝试表明，IL-17 A、IL-22、IL-1α、OSM和TNFα（Mix M5）的组合协同增加了趋化因子和抗菌肽的表达，重现了银屑病的一些特征。银屑病的其他特征是棘皮症和角质形成细胞分化标志物的下调。我们的目的是描述这些细胞因子对角质形成细胞分化的具体作用，并与银屑病病变特征进行比较。所有细胞因子都降低角质形成细胞分化标志物，但IL-22和OSM是最强大的，并且M5强烈地协同作用。此外，IL-22和OSM在体外诱导表皮增生，M5在小鼠模型中诱导表皮增厚和分化标志物表达降低，如在人银屑病皮肤病变中观察到的。这项研究强调了细胞因子在皮肤炎症反应中的确切作用。IL-22和OSM更特异性地驱动表皮增生和分化丧失，而IL-1α、IL-17 A和TNFα更多地参与天然免疫的激活。
Keratinocyte differentiation program leading to an organized epidermis plays a key role in maintaining the first line of defense of the skin. Epidermal integrity is regulated by a tight communication between keratinocytes and leucocytes, particularly under cytokine control. Imbalance of the cytokine network leads to inflammatory diseases such as psoriasis. Our attempt to model skin inflammation showed that the combination of IL-17A, IL-22, IL-1α, OSM and TNFα (Mix M5) synergistically increases chemokine and antimicrobial-peptide expression, recapitulating some features of psoriasis. Other characteristics of psoriasis are acanthosis and down-regulation of keratinocyte differentiation markers. Our aim was to characterize the specific roles of these cytokines on keratinocyte differentiation, and to compare with psoriatic lesion features. All cytokines decrease keratinocyte differentiation markers, but IL-22 and OSM were the most powerful, and the M5 strongly synergized the effects. In addition, IL-22 and OSM induced epidermal hyperplasia in vitro and M5 induced epidermal thickening and decreased differentiation marker expression in a mouse model, as observed in human psoriatic skin lesions. This study highlights the precise role of cytokines in the skin inflammatory response. IL-22 and OSM more specifically drive epidermal hyperplasia and differentiation loss while IL-1α, IL-17A and TNFα were more involved in the activation of innate immunity.
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影响因子：
21.3
作者：
Lopez, Rodolphe G.;Garcia-Silva, Susana;Nerlov, Claus
通讯作者：
Nerlov, Claus
DOI：
10.1016/s0190-9622(94)70059-1
发表时间：
1994-04-01
影响因子：
13.8
作者：
NICKOLOFF, BJ;NAIDU, Y
通讯作者：
NAIDU, Y
DOI：
10.1084/jem.20060244
发表时间：
2006-11-27
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan JR;Blumenschein W;Murphy E;Diveu C;Wiekowski M;Abbondanzo S;Lucian L;Geissler R;Brodie S;Kimball AB;Gorman DM;Smith K;de Waal Malefyt R;Kastelein RA;McClanahan TK;Bowman EP
通讯作者：
Bowman EP
DOI：
10.1038/jid.2011.24
发表时间：
2011-06
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Kim BE;Howell MD;Guttman-Yassky E;Gilleaudeau PM;Cardinale IR;Boguniewicz M;Krueger JG;Leung DY
通讯作者：
Leung DY
DOI：
10.1155/2012/718725
发表时间：
2012
期刊：
Journal of allergy
影响因子：
--
作者：
Bernard FX;Morel F;Camus M;Pedretti N;Barrault C;Garnier J;Lecron JC
通讯作者：
Lecron JC