HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster.
HIOMT drives the photoperiodic changes in the amplitude of the melatonin peak of the Siberian hamster.
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HIOMT 驱动西伯利亚仓鼠褪黑激素峰值幅度的光周期变化。
DOI：
10.1152/ajpregu.2000.278.5.r1339
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
V. Simonneaux
中科院分区：
文献类型：
--
作者：
C. Ribelayga;P. Pévet;V. Simonneaux
In the pineal, melatonin (Mel) is synthesized from serotonin by arylalkylamine-N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT). Although it is clear that AA-NAT drives the daily rhythm in Mel synthesis, the mechanisms involved in the photoperiodic changes of the amplitude of the Mel peak, as observed in the Siberian hamster, remain to be determined. We investigated the characteristics of AA-NAT and HIOMT in Siberian hamsters kept either under a short (SP) or a long photoperiod (LP). The amplitude of the nocturnal peak of Mel was about two times higher under SP than under LP, whereas AA-NAT activity was about two times smaller under SP. In contrast, a twofold increase of HIOMT activity was observed under SP compared with LP. No change in the affinity of the enzymes for their substrates was observed between the two photoperiods. Our data strongly suggest that the photoperiodic variations in the amplitude of the nocturnal peak of Mel are driven by HIOMT, thereby promoting an important physiological role for this enzyme in the seasonal regulation of Mel production.
大鼠视交叉上核是四季的时钟。
DOI：
10.1073/pnas.92.17.7754
发表时间：
1995
影响因子：
11.1
作者：
Sumová,A;Trávnícková,Z;Peters,R;Schwartz,WJ;Illnerová,H
通讯作者：
Illnerová,H