Induced deposition of bone-like hydroxyapatite on thermally oxidized titanium substrates using a spatial gap in a solution that mimics a body fluid
Induced deposition of bone-like hydroxyapatite on thermally oxidized titanium substrates using a spatial gap in a solution that mimics a body fluid
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利用模拟体液的溶液中的空间间隙在热氧化钛基材上诱导骨样羟基磷灰石沉积
DOI：
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
C. Ohtsuki
中科院分区：
文献类型：
--
作者：
A. Sugino;K. Tsuru;S. Hayakawa;K. Kikuta;Giichiro Kawachi;A. Osaka;C. Ohtsuki
我们报告的影响，使用的空间间隙上的热氧化钛基板的表面上的异质成核。在暴露于模拟体液（SBF）时在100-800°C的温度下热氧化的基底之间的空间间隙中评估骨样羟基磷灰石（BHAp）的异相成核的诱导。在SBF中浸泡7 d后，BHAp自发地沉积在高于400°C的温度下热氧化的样品表面上的差距内，但在300°C或更低的温度下热氧化的样品上没有。BHAp颗粒最容易沉积在样品表面上的差距内，所述样品在SBF中浸泡后在400°C下热氧化。较小的间隙导致更多数量的BHAp颗粒沉积在在400或500°C下热氧化的样品的表面上。我们的研究结果表明，BHAp在SBF中的形成是依赖于热氧化过程中的温度，也对样品之间的空间间隙。热氧化钛上形成BHAp的容易性随着金红石相的厚度和在热氧化过程中产生的Ti-OH基团的数量的增加而增加。除了衬底的表面结构之外，空间间隙被认为是增强BHAp沉积的重要参数。由于BHAp的形成允许骨传导在骨缺损中植入后发生，因此可以通过使用适当的基质空间设计进行处理来设计对骨具有高生物亲和力的钛基植入物。
We report on the effect of using a spatial gap on heterogeneous nucleation on the surface of thermally oxidized titanium substrates. Induction of heterogeneous nucleation of bone-like hydroxyapatite (BHAp) was evaluated in the spatial gaps between substrates that were thermally oxidized at temperatures of 100-800°C on exposure to a simulated body fluid (SBF). After soaking in a SBF for 7 d, BHAp spontaneously deposited inside the gap on the surface of samples that were thermally oxidized at temperatures above 400°C, but not on samples that were thermally oxidized at temperatures of 300°C or less. Among the substrates studied, BHAp particles were most readily deposited inside the gap on the surface of the samples that were thermally oxidized at 400°C after soaking in an SBF. A smaller gap led to a higher number of BHAp particles being deposited on the surface of the samples that were thermally oxidized at 400 or 500°C. Our results suggest that the formation of BHAp in a SBF is dependent on the temperature during thermal oxidization, and also on the spatial gap between the samples. The ease of formation of BHAp on thermally oxidized titanium increases with increasing thickness of the rutile phase and the number of Ti-OH groups, which are produced during the thermal oxidization process. In addition to the surface structure of the substrates, the spatial gap is regarded as an important parameter for enhancing the deposition of BHAp. Since the formation of BHAp allows osteoconduction to occur after implantation in a bony defect, it is possible to design titanium-based implants with a high biological affinity to bone by processing using an appropriate spatial design of the substrate.
影响因子：
14
作者：
HEALY, KE;DUCHEYNE, P
通讯作者：
DUCHEYNE, P
钛在模型生理环境中被动溶解的机制。
DOI：
10.1002/jbm.820260305
发表时间：
1992
期刊：
Journal of biomedical materials research
影响因子：
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作者：
Healy,KE;Ducheyne,P
通讯作者：
Ducheyne,P