Temporal Pitch Sensitivity in an Animal Model: Psychophysics and Scalp Recordings : Temporal Pitch Sensitivity in Cat.
Temporal Pitch Sensitivity in an Animal Model: Psychophysics and Scalp Recordings : Temporal Pitch Sensitivity in Cat.
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DOI：
10.1007/s10162-022-00849-z
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发表时间：
2022-08
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--
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耳蜗植入体（CI）使用者对电刺激所传达的时间音高表现出有限的敏感性，导致对音乐和噪音中言语的感知受损。在猫的神经生理学研究表明，这种限制是由于，在一定程度上，由电耳蜗刺激激活的脑干通路的颞叶精细结构（TFS）的传输不良。然而，在同一动物模型中，这种神经限制如何影响感知仍然是未知的。出于这个原因，我们开发了时间的非侵入性心理物理和电生理测量（即，听觉正常（NH）的猫被呈现由频带限制的谐波复合物组成的声学脉冲串，其模拟基底耳蜗的CI刺激，同时去除耳蜗的激励线索。在心理物理过程中，受过训练的猫检测到从基础脉搏率到更高脉搏率的变化。在头皮记录程序中，皮质诱发的声学变化复合体（ACC）和脑干产生的频率跟随反应（FFR）被同时记录在镇静猫的脉冲序列之间交替的基础和更高的利率。对时间音高的感知敏感度范围与人类大致相似，但变化率略高。ACC在很大程度上抑制了这些感知模式，验证了其作为时间音高敏感度的客观测量的用途。相比之下，锁相血流储备分数显示所有测试脉率的脑干编码较强。这些措施表明，猫的知觉灵敏度，在没有耳蜗的地方线索的音高，并可能是有价值的评价神经机制的时间音高感知的猫动物模型的刺激CI或新的听觉假体。
Cochlear implant (CI) users show limited sensitivity to the temporal pitch conveyed by electric stimulation, contributing to impaired perception of music and of speech in noise. Neurophysiological studies in cats suggest that this limitation is due, in part, to poor transmission of the temporal fine structure (TFS) by the brainstem pathways that are activated by electrical cochlear stimulation. It remains unknown, however, how that neural limit might influence perception in the same animal model. For that reason, we developed non-invasive psychophysical and electrophysiological measures of temporal (i.e., non-spectral) pitch processing in the cat. Normal-hearing (NH) cats were presented with acoustic pulse trains consisting of band-limited harmonic complexes that simulated CI stimulation of the basal cochlea while removing cochlear place-of-excitation cues. In the psychophysical procedure, trained cats detected changes from a base pulse rate to a higher pulse rate. In the scalp-recording procedure, the cortical-evoked acoustic change complex (ACC) and brainstem-generated frequency following response (FFR) were recorded simultaneously in sedated cats for pulse trains that alternated between the base and higher rates. The range of perceptual sensitivity to temporal pitch broadly resembled that of humans but was shifted to somewhat higher rates. The ACC largely paralleled these perceptual patterns, validating its use as an objective measure of temporal pitch sensitivity. The phase-locked FFR, in contrast, showed strong brainstem encoding for all tested pulse rates. These measures demonstrate the cat’s perceptual sensitivity to pitch in the absence of cochlear-place cues and may be valuable for evaluating neural mechanisms of temporal pitch perception in the feline animal model of stimulation by a CI or novel auditory prostheses.
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影响因子：
3.8
作者：
Okamoto H;Teismann H;Kakigi R;Pantev C
通讯作者：
Pantev C
DOI：
10.1111/j.1460-9568.2010.07527.x
发表时间：
2011-02
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Bidelman GM;Krishnan A;Gandour JT
通讯作者：
Gandour JT
影响因子：
16.6
作者：
Coffey, Emily B. J.;Nicol, Trent;Kraus, Nina
通讯作者：
Kraus, Nina
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1121/10.0002668
发表时间：
2020-11
期刊：
The Journal of the Acoustical Society of America
影响因子：
--
作者：
Gockel HE;Moore BCJ;Carlyon RP
通讯作者：
Carlyon RP