Hepatitis C prevalence and quality of health services among HIV-positive mothers in the Democratic Republic of the Congo.
Hepatitis C prevalence and quality of health services among HIV-positive mothers in the Democratic Republic of the Congo.
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DOI：
10.1038/s41598-022-05014-3
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发表时间：
2022-01-26
影响因子：
4.6
通讯作者：
CQI-PMTCT study team
中科院分区：
文献类型：
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作者：
Thompson P;Mpody C;Sayre W;Rigney C;Tabala M;Ravelomanana NLR;Malongo F;Kawende B;Behets F;Okitolonda E;Yotebieng M;CQI-PMTCT study team
尽管有有效的抗病毒药物，丙型肝炎病毒（HCV）仍导致整个非洲与肝脏相关的发病率和死亡率。 HCV 在刚果民主共和国 (DRC) 流行，但妊娠期间 HCV/HIV 双重感染的数据有限。我们估计了刚果金沙萨省孕妇中 HCV/HIV 混合感染的患病率和危险因素。这项横断面研究是一项正在进行的随机试验的子研究，旨在评估预防 HIV 母婴传播 (PMTCT) 的持续质量改进干预措施 (CQI)（CQI-PMTCT 研究，NCT03048669）。 CQI-PMTCT 队列中的 HIV 感染女性接受了 HCV 检测，并使用逻辑回归评估了危险因素。刚果妇女中 HCV/HIV 混合感染率为 0.83% (95% CI 0.43-1.23)。丙肝病毒检测呈阳性的女性更年轻，更有可能生活在城市地区，并且与产后相比，在怀孕期间检测呈阳性的可能性更大。 HCV 阳性女性感染乙型肝炎病毒 (HBV) 的几率显着较高 (aOR 13.87 [3.29,58.6])。根据服务准备指数 (SRI) 衡量，HCV 感染与卫生机构的总体能力之间存在负相关关系（aOR：每单位增加 0.92 [0.86,0.98]）。到农村、营利性和总统紧急援助计划 (PEPFAR) 资助的医疗机构就诊的女性丙肝病毒检测结果更有可能呈阳性。总之，本研究确定刚果妇女中 HCV/HIV 双重感染的患病率<<1%。我们还确定 HBV 感染是 HCV/HIV 双重感染的主要危险因素。三重感染者应接受护理，并且在未来的研究中应解决与设施相关的 HCV 患病率差异。
Hepatitis C virus (HCV) contributes to liver-related morbidity and mortality throughout Africa despite effective antivirals. HCV is endemic in the Democratic Republic of the Congo (DRC) but data on HCV/HIV co-infection in pregnancy is limited. We estimated the prevalence of and risk factors for HCV/HIV co-infection among pregnant women in the Kinshasa province of the DRC. This cross-sectional study was conducted as a sub-study of an ongoing randomized trial to assess continuous quality improvement interventions (CQI) for prevention of mother-to-child transmission (PMTCT) of HIV (CQI-PMTCT study, NCT03048669). HIV-infected women in the CQI-PMTCT cohort were tested for HCV, and risk factors were evaluated using logistic regression. The prevalence of HCV/HIV co-infection among Congolese women was 0.83% (95% CI 0.43-1.23). Women who tested positive for HCV were younger, more likely to live in urban areas, and more likely to test positive during pregnancy versus postpartum. HCV-positive women had significantly higher odds of infection with hepatitis B virus (HBV) (aOR 13.87 [3.29,58.6]). An inverse relationship was noted between HCV infection and the overall capacity of the health facility as measured by the service readiness index (SRI) (aOR:0.92 [0.86,0.98] per unit increase). Women who presented to rural, for-profit and PEPFAR-funded health facilities were more likely to test positive for HCV. In summary, this study identified that the prevalence of HCV/HIV co-infection was < 1% among Congolese women. We also identified HBV infection as a major risk factor for HCV/HIV co-infection. Individuals with triple infection should be linked to care and the facility-related differences in HCV prevalence should be addressed in future studies.
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影响因子：
6
作者：
Yotebieng, Marcel;Mpody, Christian;Tshibuabua, Marie
通讯作者：
Tshibuabua, Marie
影响因子：
3.7
作者：
Mora N;Adams WH;Kliethermes S;Dugas L;Balasubramanian N;Sandhu J;Nde H;Small C;Jose J;Scaglione S;Layden JE
通讯作者：
Layden JE
DOI：
10.1093/infdis/jiaa389
发表时间：
2022-08-26
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.8
作者：
Sulkowski, Mark S.;Mehta, Shruti H.;Thomas, David L.
通讯作者：
Thomas, David L.
影响因子：
1
作者：
Ogwu-Richard, Sandra Olukemi;Ojo, David Ajiboye;Okonko, Iheanyi Omezuruike
通讯作者：
Okonko, Iheanyi Omezuruike