The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture.
The Chinese skeleton: insights into microstructure that help to explain the epidemiology of fracture.
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DOI：
10.1038/boneres.2014.9
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发表时间：
2014
期刊：
影响因子：
12.7
通讯作者：
Walker, Marcella D.
中科院分区：
文献类型：
--
作者：
Cong, Elaine;Walker, Marcella D.
骨质疏松性骨折是全球范围内的一个主要公共卫生问题，但在不同种族和地理区域的发病率差异很大。最近的研究表明，在亚洲人群中，骨质疏松性骨折的发病率正在上升。比较不同种族的区域骨密度和骨折的研究通常表明，包括中国人在内的亚洲人的骨密度较低，但这并不反映他们非椎骨骨折的风险相对较低。相比之下，中国人的脊椎骨折率相对较高，与白人相似。尽管中国人的骨密度较低，但其某些类型骨折的风险却很低，这一矛盾现象已被骨骼成像的最新进展部分阐明。非侵入性评估骨质量的新技术表明，中国人通过髋关节几何形状和微观结构骨骼组织的差异来补偿较小的骨尺寸。评估影响骨重建以及骨获得和丢失的种族差异的因素的研究可能会进一步阐明骨微观结构的种族差异。对中国人骨骼微观结构的了解不仅有助于解释中国人骨折的流行病学，而且也可能为其他种族的骨折流行病学提供见解。
Osteoporotic fractures are a major public health problem worldwide, but incidence varies greatly across racial groups and geographic regions. Recent work suggests that the incidence of osteoporotic fracture is rising among Asian populations. Studies comparing areal bone mineral density and fracture across races generally indicate lower bone mineral density in Asian individuals including the Chinese, but this does not reflect their relatively low risk of non-vertebral fractures. In contrast, the Chinese have relatively high vertebral fracture rates similar to that of Caucasians. The paradoxically low risk for some types of fractures among the Chinese despite their low areal bone mineral density has been elucidated in part by recent advances in skeletal imaging. New techniques for assessing bone quality non-invasively demonstrate that the Chinese compensate for smaller bone size by differences in hip geometry and microstructural skeletal organization. Studies evaluating factors influencing racial differences in bone remodeling, as well as bone acquisition and loss, may further elucidate racial variation in bone microstructure. Advances in understanding the microstructure of the Chinese skeleton have not only helped to explain the epidemiology of fracture in the Chinese, but may also provide insight into the epidemiology of fracture in other races as well.
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