Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: a retrospective study.
Association between changes in pancreatic morphology and vascular complications in subjects with type 2 diabetes mellitus: a retrospective study.
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DOI：
10.1038/s41598-022-21688-1
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发表时间：
2022-10-13
影响因子：
4.6
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中科院分区：
文献类型：
--
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胰腺体积减小，胰腺脂肪增加，胰腺边缘呈锯齿状是2型糖尿病患者胰腺的特征性形态学改变。本回顾性研究旨在阐明2型糖尿病患者行腹部磁共振成像后胰腺形态学改变的临床意义。平均年龄59.1±16.3岁，平均HbA1c值8.9±2.3%。经体表面积（BSA）校正的胰腺体质量（49.4±15.3 cm3 vs. 60.9±7.8 cm3），糖尿病患者较糖耐量正常者低，但未达到统计学意义。bsa校正胰腺体积与年龄、糖尿病病程、糖白蛋白、平均和最大IMT呈负相关，与HOMA2-β呈正相关。与糖耐量正常的受试者相比，糖尿病患者更常观察到胰腺边缘呈锯齿状（74.1%对14.3%）。锯齿状改变的受试者年龄较大，HbA1c较高，且内脏脂肪面积明显较大。有锯齿状变化的受试者经bsa校正后的胰腺体积明显更小，有锯齿状变化的受试者平均IMT明显更厚。此外，晚期糖尿病视网膜病变和糖尿病肾病更常见于有锯齿状变化的受试者。综上所述，bsa校正的胰腺体积减小和锯齿状变化与2型糖尿病患者血管并发症的进展有关。
Decreased pancreatic volume, increased pancreatic fat mass, and serrated pancreatic margins are characteristic morphological changes of the pancreas in subjects with type 2 diabetes mellitus. This retrospective study aimed to clarify the clinical significance of pancreatic morphological changes in subjects with type 2 diabetes mellitus who underwent abdominal magnetic resonance imaging. The mean age and HbA1c value were 59.1 ± 16.3 years old and 8.9 ± 2.3%, respectively. Pancreatic body mass corrected for body surface area (BSA) in subjects with diabetes mellitus was lower compared to those in normal glucose tolerance (49.4 ± 15.3 cm3 vs. 60.9 ± 7.8 cm3), although it did not reach a statistic significance. There was a negative correlation between BSA-corrected pancreatic volume and age, duration of diabetes, glycoalbumin, mean and max IMT, and there was a positive correlation between BSA-corrected pancreatic volume and HOMA2-β. Serration of the pancreatic limbus was more often observed in subjects with diabetes mellitus compared to those in normal glucose tolerance (74.1% vs. 14.3%). Subjects with serrated changes were older and had higher HbA1c, and visceral fat area was significantly larger in subjects with serrated changes. BSA-corrected pancreatic volume in subjects with serrated changes was significantly smaller, and mean IMT was significantly thicker in subjects with serrulation. Furthermore, advanced diabetic retinopathy and diabetic nephropathy were more often observed in subjects with serrated changes. Taken together, decreased BSA-corrected pancreatic volume and serrated changes were associated with the progression of vascular complications in subjects with type 2 diabetes mellitus.
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