Metabolic Challenges in Anticancer CD8 T Cell Functions.
Metabolic Challenges in Anticancer CD8 T Cell Functions.
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DOI：
10.4110/in.2023.23.e9
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发表时间：
2023-03
期刊：
影响因子：
6
通讯作者：
Kim, Minsoo
中科院分区：
文献类型：
--
作者：
Amitrano, Andrea M.;Kim, Minsoo
Cancer immunotherapies continue to face numerous obstacles in the successful treatment of solid malignancies. While immunotherapy has emerged as an extremely effective treatment option for hematologic malignancies, it is largely ineffective against solid tumors due in part to metabolic challenges present in the tumor microenvironment (TME). Tumor-infiltrating CD8+ T cells face fierce competition with cancer cells for limited nutrients. The strong metabolic suppression in the TME often leads to impaired T-cell recruitment to the tumor site and hyporesponsive effector functions via T-cell exhaustion. Growing evidence suggests that mitochondria play a key role in CD8+ T-cell activation, migration, effector functions, and persistence in tumors. Therefore, targeting the mitochondrial metabolism of adoptively transferred T cells has the potential to greatly improve the effectiveness of cancer immunotherapies in treating solid malignancies.
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