Smoking and tardive dyskinesia: lack of involvement of the CYP1A2 gene.
Smoking and tardive dyskinesia: lack of involvement of the CYP1A2 gene.
复制标题
吸烟和迟发性运动障碍：缺乏 CYP1A2 基因的参与。
DOI：
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复制
发表时间：
2003
影响因子：
4.3
通讯作者：
Mythily
中科院分区：
文献类型：
--
作者：
S. Chong;E. Tan;Chay;Mythily
客观化
[目的]探讨吸烟与精神分裂症患者迟发性运动障碍(TD)的关系，并探讨中国人迟发性运动障碍(TD)与细胞色素P4501A2(CYP1A2)基因的关系。
方法
291名符合DSM-IV诊断标准的精神分裂症患者被纳入研究。采用异常不自主运动量表评定运动障碍，按Sucoler和Kane标准评定运动障碍。收集了人口统计学和临床数据以及有关吸烟习惯的信息，并对有良好吸烟史的华裔患者随后进行了CYP1A2基因分型。
结果
104例有吸烟史的患者中有43例(41.3%)被诊断为TD，187例非吸烟者中52例(27.8%)被诊断为TD。吸烟者的TD患病率显著高于非吸烟者(CHI2=5.57，p=0.018)。以TD为因变量的Logistic回归显示吸烟者患TD的风险显著增加(p<；0.005)。对中国吸烟者进行的CYP1A2基因分型结果显示，患有TD和不伴有TD的吸烟者在基因或等位基因分布上没有显著差异。
结论
与其他研究一致，吸烟者中TD的患病率显著高于非吸烟者；然而，我们没有发现CYP1A2的C-->；A基因多态性与TD之间的关联。
OBJECTIVE
To establish if there is an association between cigarette smoking and tardive dyskinesia (TD) in patients with schizophrenia and to evaluate the role of the CYP1A2 polymorphism in TD in patients of Chinese descent.
METHOD
Two-hundred and ninety-one patients diagnosed with schizophrenia according to DSM-IV criteria were included in the study. Dyskinesia was assessed by the Abnormal Involuntary Movement Scale and TD by the criteria of Schooler and Kane. Demographic and clinical data and information on smoking habits were collected, and patients of Chinese descent with a well established smoking history were subsequently genotyped for CYP1A2.
RESULTS
Forty-three (41.3%) of the 104 patients with a history of smoking and 52 (27.8%) of the 187 non-smokers were diagnosed with TD. The prevalence of TD was significantly higher among smokers than non-smokers (chi2 = 5.57, p = 0.018). Logistic regression using TD as the dependent variable revealed smokers to be at a significantly higher risk for TD (p < 0.005). Genotyping of smokers of Chinese descent for CYP1A2 polymorphism revealed no significant differences in the genotypic or allelic distribution between those with and without TD.
CONCLUSIONS
Consistent with other studies, the prevalence of TD was significantly higher among smokers than non-smokers; however, we did not find an association between the C --> A genetic polymorphism of CYP1A2 and TD.
DOI：
10.1176/ajp.143.8.993
发表时间：
1986
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Hughes,JR;Hatsukami,DK;Mitchell,JE;Dahlgren,LA
通讯作者：
Dahlgren,LA
尼古丁依赖和精神分裂症。
DOI：
10.1176/ps.45.3.204
发表时间：
1994
期刊：
Hospital & community psychiatry
影响因子：
--
作者：
Ziedonis,DM;Kosten,TR;Glazer,WM;Frances,RJ
通讯作者：
Frances,RJ